| name | Metronidazole Topical Gel |
| classification | Antiprotozoal, Antibacterial |
| pharmacokinetics | Metronidazole topical gel is primarily absorbed through the skin and into the local tissues. The extent of systemic absorption is low, but can vary based on factors like concentration, duration of application, and the patient's skin condition. Peak concentrations in the blood are generally low and transient. The elimination half-life is about 8-10 hours for the active drug, and 10-15 hours for metabolites. Excretion primarily occurs through the kidneys. The extent of absorption may be affected by factors including the concentration of the gel, the extent and duration of application, the integrity of the skin at the application site, concomitant medications, and the patient's individual characteristics. |
| suggested dosage | Dosage varies depending on the specific condition being treated. Consult with a healthcare professional for appropriate dosage based on the individual patient's needs. |
| indications | Metronidazole topical gel is used primarily for the treatment of skin infections caused by anaerobic bacteria or protozoa, including:
* Acne (in conjunction with other treatments)
* Bacterial infections of the skin
* Skin infections caused by anaerobic bacteria (e.g., *Bacteroides*, *Fusobacterium*) |
| safety in pregnancy | Limited data on use during pregnancy; should only be used if the potential benefit outweighs the potential risk. Discuss with a healthcare professional before using during pregnancy. |
| safety in breastfeeding | Metronidazole has been detected in breast milk, but generally in low concentrations and in a form unlikely to cause harm to a breastfeeding infant. Consult with a healthcare professional before using. |
| side effects | Common side effects may include local skin reactions such as irritation, redness, itching, burning, or rash. Less common, but more serious, side effects may include allergic reactions, systemic absorption with systemic side effects (as mentioned above). Always seek medical attention if serious side effects occur. |
| alternatives | |
| contraindications | Hypersensitivity to metronidazole or any component of the gel. Caution in patients with impaired renal function as excretion may be affected. |
| interactions | Possible interactions with other medications; consult with a healthcare professional. Avoid concomitant use of alcohol or alcohol-containing products due to possible adverse reactions with systemic metronidazole. |
| warnings and precautions | Avoid contact with eyes. Monitor for any adverse reactions; discontinue use if irritation or other issues arise. Use as directed by a healthcare professional. The gel should not be used for oral administration. |
| additional informations | This information is for educational purposes only and does not constitute medical advice. A healthcare professional should be consulted before starting any treatment, especially for a patient with underlying conditions. Important to remember that dosages and indications may vary based on the specific product and brand. Consult package insert or physician for more detailed information. |
| patient details | |
