| name | Miconazole |
| Classification | Anti-fungal (azoles) |
| Pharmacokinetics | Miconazole is poorly absorbed orally and is primarily used topically. Absorption from topical applications varies depending on the formulation and site of application. The drug is metabolized in the liver and primarily eliminated via the kidneys. Plasma protein binding is moderate. Systemic absorption is generally low with topical use, but can be significant with oral or vaginal formulations. The exact pharmacokinetic parameters for topical use in a male patient of 25 years and 70kg are not readily available and are not a primary focus of clinical interest. |
| suggested dosage | Dosage varies greatly depending on the specific formulation (oral, topical, vaginal). It is crucial to consult a physician or refer to the product information leaflet for precise dosage instructions tailored to the individual patient and condition. General advice cannot be provided for all forms. |
| indications | Topical Miconazole is primarily used to treat superficial fungal skin infections (tinea), such as athlete's foot, jock itch, ringworm, and yeast infections (candidiasis). Oral miconazole is used for severe systemic fungal infections, but this is less common and usually under strict medical supervision. The specific indication should guide dosage, duration of treatment, and form of the drug. |
| safety in pregnancy | Limited data exists on the safety of miconazole during pregnancy. While the risk appears to be low, it is crucial to discuss the benefits and risks with a physician, especially during pregnancy. |
| safety in breastfeeding | Limited data exists on the safety of miconazole while breastfeeding. It is prudent to consult with a medical professional before using miconazole during breastfeeding. |
| side effects | Common side effects of topical miconazole can include skin irritation, redness, itching, burning, or stinging. Less frequent side effects may include allergic reactions. Systemic absorption of miconazole, especially with oral formulations, might cause nausea, vomiting, or liver dysfunction. Always consult the prescribing information. |
| alternatives | |
| contraindications | Miconazole is contraindicated in patients with known hypersensitivity or allergy to the drug or any of its components. Certain other underlying health conditions may require caution and close monitoring when using miconazole; consult with a physician. |
| interactions | Miconazole can interact with other medications, potentially altering their efficacy or increasing the risk of side effects. Specific interactions should be evaluated by a healthcare professional. |
| warnings and precautions | Avoid contact with eyes. If swallowed, seek immediate medical attention. Individuals with underlying liver or kidney conditions may need special monitoring. Stop use and contact a physician if symptoms worsen or do not improve after a specified period. Always follow prescribed dosages and usage instructions. |
| additional informations | Miconazole is available in various formulations, including creams, lotions, powders, and oral tablets, depending on the intended use. Always refer to the package insert or consult a healthcare professional for detailed information regarding specific formulations and dosing, especially if other medical conditions exist. |
| patient information | |
