| name | Clotrimazole |
| classification | Anti-fungal (azoles) |
| pharmacokinetics | Clotrimazole is a broad-spectrum antifungal agent primarily effective against dermatophytes, yeasts, and some molds. It works by interfering with the synthesis of ergosterol, a critical component of fungal cell membranes. Topical application results in limited absorption with minimal systemic exposure. Metabolism primarily occurs in the liver, and excretion is primarily through the kidneys and feces. Plasma concentrations are low after topical administration, with peak concentrations observed in the stratum corneum. |
| suggested dosage | Dosage is dependent on the route of administration and the specific condition. Consult a physician or pharmacist for appropriate dosage in a specific case. Topical application follows product-specific instructions. |
| indications | Topical clotrimazole treats superficial fungal infections of the skin, such as athlete's foot, ringworm, and yeast infections (candidiasis). It may also be used for vaginal infections. |
| safety in pregnancy | Limited data exist regarding safety during pregnancy. Topical use is generally considered safe; however, caution is advised during the first trimester. Consult a healthcare professional before using clotrimazole if pregnant or trying to conceive. |
| safety in breastfeeding | Limited data available. Topical use results in minimal absorption, suggesting low amounts in breast milk. Consult a healthcare professional before using topical clotrimazole if breastfeeding. |
| side effects | Common side effects include mild skin irritation (redness, itching, burning). Rare occurrences of more severe adverse effects (allergic reactions, contact dermatitis, hypersensitivity) are possible. Systemic side effects are minimal due to limited absorption. |
| alternatives | |
| contraindications | Hypersensitivity to clotrimazole or other azole antifungals. Severe skin conditions or open wounds may necessitate alternative treatments. |
| interactions | Limited drug-drug interactions are known. Inform your doctor of all medications you are taking. |
| warnings and precautions | For topical use only. Avoid contact with eyes. Do not use on large open wounds. If symptoms worsen or do not improve, consult a healthcare professional. Follow product labeling carefully. |
| additional informations | This information is for general knowledge and informational purposes only, and should not substitute professional medical advice. Always consult a healthcare professional before using any medication, especially if you have underlying health conditions, are pregnant, or breastfeeding. Individual responses may vary. Dosage and duration should be determined by a healthcare provider. |
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