| name | Ranitidine |
| classification | H2-receptor antagonist |
| pharmacokinetics | | absorption | Rapidly absorbed from the GI tract. | | distribution | Distributed throughout the body; crosses the blood-brain barrier in small amounts. | | metabolism | Metabolized primarily in the liver, and the primary metabolite is inactive. | | excretion | Excreted primarily in the urine. |
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| suggested dosage | | adults | | usual | 150 mg twice daily | | max | 300 mg/day |
| | notes | Dosage may vary depending on the specific condition being treated. Always follow the prescribed dosage and consult a doctor for specific guidance. **Important Note:** The safety and availability of Ranitidine are currently under review due to potential N-nitrosodimethylamine (NDMA) contamination in some batches. Do not use any ranitidine product unless specifically approved for use in your region and by your healthcare provider. Consult the most up-to-date product information. |
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| indications | | 1 | Peptic ulcer disease | | 2 | Gastroesophageal reflux disease (GERD) | | 3 | Zollinger-Ellison syndrome | | 4 | Hypersecretory conditions |
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| safety in pregnancy | | category | Category B | | details | Limited data suggests no risk to the fetus during pregnancy. However, consult a doctor regarding use. Consult the most up-to-date medical information for current recommendations. |
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| safety in breastfeeding | | details | Ranitidine passes into breast milk in small amounts. While generally considered safe, consult a doctor before breastfeeding. Consult the most up-to-date medical information for current recommendations. |
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| side effects | | 1 | Headache | | 2 | dizziness | | 3 | constipation | | 4 | diarrhea | | 5 | nausea | | 6 | vomiting | | 7 | abdominal pain | | 8 | rash | | 9 | pruritus | | 10 | liver function abnormalities | | 11 | rarely, severe allergic reactions | | 12 | aplastic anemia | | 13 | leukopenia | | 14 | thrombocytopenia | | 15 | Note: Rare cases of N-nitrosodimethylamine (NDMA) have been reported in some batches in the past. Consult up-to-date safety information from regulatory bodies and manufacturers. |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to ranitidine or other H2-receptor antagonists | | 2 | Severe hepatic impairment | | 3 | Use with caution in patients with a history of blood disorders. |
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| interactions | | 1 | | drug | Cimetidine | | mechanism | Inhibits ranitidine metabolism | | effect | May increase ranitidine levels | | management | Monitor closely for adverse effects. Consult the prescribing information for specific guidance. |
| | 2 | | drug | Ketoconazole | | mechanism | Inhibits ranitidine metabolism | | effect | May increase ranitidine levels | | management | Monitor closely for adverse effects. Consult the prescribing information for specific guidance. |
| | 3 | | drug | CYP450 inhibitors | | mechanism | Potential inhibition of ranitidine metabolism | | effect | May increase ranitidine levels | | management | Monitor closely for adverse effects. Consult the prescribing information for specific guidance. |
| | 4 | | drug | warfarin | | mechanism | Possible interaction (mechanism unclear) | | effect | Potential increased bleeding risk | | management | Monitor closely for bleeding problems. Consult the prescribing information for specific guidance. |
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| warnings and precautions | | 1 | Caution in patients with pre-existing liver disease | | 2 | Patients should be monitored for signs of hypersensitivity reactions | | 3 | Monitor renal function in patients with renal impairment | | 4 | Patients should be cautioned to avoid driving or operating machinery if dizziness occurs. Always consult the most up-to-date product information. |
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| additional information | | 1 | Information on Ranitidine is constantly evolving. The most up-to-date safety data on N-nitrosodimethylamine (NDMA) contamination should be reviewed from official sources. Consult with your healthcare provider. | | 2 | Do not use any ranitidine product not specifically approved for usage by your region. | | 3 | Always consult a healthcare professional for appropriate use in your situation. The information provided is not a substitute for professional medical advice. |
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| patient info | |
