| name | Famotidine |
| classification | Histamine H2 receptor antagonist |
| pharmacokinetics | | absorption | Rapidly absorbed after oral administration, peak plasma concentrations achieved within 1-2 hours. | | distribution | Distributed throughout the body, with high concentrations in gastric mucosa. | | metabolism | Metabolism is primarily hepatic, with minimal first-pass effect. | | excretion | Excreted primarily in urine as inactive metabolites, with a half-life of approximately 3 hours. |
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| suggested dosage | | adult | | general | The typical dose is 20 mg once daily, but the range is flexible and tailored to individual patient response and treatment need. | | specific cases | In patients with severe reflux disease, higher doses (up to 40 mg daily) may be required. Doses should be adjusted based on individual clinical needs. |
| | patient specific | | weight | Weight is not a major determinant for dosage adjustments in healthy adults. | | age | Dosage adjustments are usually not required in healthy adults aged 25. |
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| indications | | 1 | Treatment of peptic ulcer disease | | 2 | Prevention of stress-related ulcers | | 3 | Treatment of gastroesophageal reflux disease (GERD) | | 4 | Treatment of Zollinger-Ellison syndrome |
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| safety in pregnancy | | category | Category B | | description | Famotidine is generally considered safe for use during pregnancy. However, more studies in pregnant women are needed. |
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| safety in breastfeeding | | description | Famotidine is present in breast milk, but at low levels. No significant adverse effects have been reported in breastfed infants. The drug is generally considered safe to use while breastfeeding. |
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| side effects | | 1 | Headache | | 2 | Diarrhea | | 3 | Constipation | | 4 | Abdominal pain | | 5 | Nausea | | 6 | Vomiting | | 7 | Dizziness | | 8 | Fatigue | | 9 | Rash | | 10 | Pruritus (itching) | | 11 | Rarely, serious liver problems (hepatitis, jaundice), blood disorders (anemia, thrombocytopenia) |
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| alternatives | |
| contraindications | | 1 | Hypersensitivity to famotidine or other ingredients in the drug. | | 2 | Severe liver disease |
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| interactions | | 1 | May increase the risk of side effects with drugs such as alcohol or other medications that are metabolized by the liver. | | 2 | May decrease the effectiveness of certain medications (such as digoxin) or increase levels of medications (such as warfarin). |
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| warnings and precautions | | 1 | Monitor liver function tests, especially in patients with pre-existing liver conditions. | | 2 | Use caution in patients with kidney impairment, as excretion may be affected. | | 3 | Do not use if pregnant or breastfeeding unless advised by a healthcare professional. Thorough discussion with a doctor is essential. | | 4 | Careful monitoring is advised if used with other medications to avoid drug interactions. |
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| additional informations | | drug formulations | | | important notes | Always follow the prescribed dosage and instructions provided by your healthcare provider. |
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