| name | Esomeprazole |
| classification | Proton Pump Inhibitors (PPIs) |
| pharmacokinetics | Esomeprazole is a potent inhibitor of gastric acid secretion. It is rapidly absorbed after oral administration, with peak plasma concentrations typically occurring within 1-4 hours. The drug is primarily metabolized in the liver and has a half-life of approximately 1 hour. Esomeprazole is highly protein-bound and is excreted primarily in the urine as metabolites. |
| suggested dosage | | general | The typical adult dose for most conditions is 20 mg once daily. Doses may vary based on the specific condition and the patient's response. Consult a healthcare professional for specific dosage recommendations. | | male patient 25y 70kg | 20 mg orally once daily. Adjustments based on individual needs may be necessary. A healthcare professional should oversee this. |
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| indications | | 1 | Gastroesophageal reflux disease (GERD) | | 2 | Peptic ulcers | | 3 | Zollinger-Ellison syndrome | | 4 | Erosive esophagitis | | 5 | Gastritis |
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| safety in pregnancy | Limited data is available, and thus it is best to avoid use in pregnancy if possible unless the benefit of treatment outweighs the potential risk to the developing fetus. This should be discussed carefully with a healthcare provider. The use during specific trimesters might impact the fetus differently. Pregnancy should be considered a contraindication in some circumstances. |
| safety in breastfeeding | Esomeprazole passes into breast milk in small amounts. While generally considered safe, it is still prudent to discuss its use with a healthcare professional if breastfeeding. |
| side effects | | 1 | Headache | | 2 | Diarrhea | | 3 | Constipation | | 4 | Nausea | | 5 | Abdominal pain | | 6 | Flatulence | | 7 | Vomiting | | 8 | Dizziness | | 9 | Fatigue | | 10 | Rare but potentially serious: Vitamin B12 deficiency (with long-term use), Clostridium difficile infection, fractures (especially in long-term use) | | 11 | Skin rash | | 12 | Muscle pain | | 13 | Joint pain |
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| alternatives | |
| contraindications | | 1 | Hypersensitivity to esomeprazole or any of its components | | 2 | Patients with known severe liver disease |
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| interactions | | 1 | Drugs that are metabolized by the liver (e.g., certain anticoagulants, anti-inflammatory medications, etc.) | | 2 | Drugs that can decrease stomach acid (e.g., H2 blockers) | | 3 | Drugs that affect the absorption of other medications (e.g., digoxin, phenytoin, etc.) |
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| warnings and precautions | | 1 | Long-term use can result in a deficiency of vitamin B12. This is more likely to happen with long-term use, especially in patients who may not be consuming adequate amounts of vitamin B12 in their diet | | 2 | The patient must report any signs of infection, especially diarrhea that is severe or prolonged. | | 3 | Patients with underlying conditions should discuss appropriate dosage and use with their healthcare provider. | | 4 | Patients taking other medications should inform their doctor or pharmacist of all medications taken to avoid potential interactions. |
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| additional information | This information is for general knowledge and informational purposes only, and does not constitute medical advice. Always consult with a qualified healthcare professional for diagnosis and treatment. |
| patient specific details | |
