| name | Pantoprazole |
| classification | Proton Pump Inhibitors (PPIs) |
| pharmacokinetics | Pantoprazole is rapidly absorbed after oral administration. It is primarily metabolized in the liver and its active metabolite is responsible for most of its effects. The elimination half-life is approximately 1 hour, but the effect of the drug can last longer. It inhibits the gastric proton pump, leading to reduced acid production. |
| suggested dosage | | adult male 25 70kg | Usually 20-40 mg once daily. Consult a physician for specific dosage based on the individual patient's condition and treatment goals. | | notes | Dosage may vary depending on the indication (e.g., GERD, ulcers). |
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| indications | | 1 | Gastroesophageal Reflux Disease (GERD) | | 2 | Peptic Ulcer Disease | | 3 | Zollinger-Ellison Syndrome | | 4 | Prevention of NSAID-induced gastric ulcers |
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| safety in pregnancy | Limited data is available. While not definitively classified as harmful, use should be considered only if the benefit clearly outweighs the potential risk. Consult a physician. |
| safety in breastfeeding | Pantoprazole is secreted into breast milk, but the clinical significance of this is uncertain. Monitor for any potential side effects in the infant. Consult a physician or lactation consultant. |
| side effects | | 1 | Headache | | 2 | Diarrhea | | 3 | Constipation | | 4 | Nausea | | 5 | Abdominal pain | | 6 | Vomiting | | 7 | Flatulence | | 8 | Fatigue | | 9 | Dizziness | | 10 | Vertigo | | 11 | Increased risk of Clostridium difficile infection | | 12 | Vitamin B12 deficiency (with long-term use) | | 13 | Rarely: skin rash, itching, Stevens-Johnson syndrome |
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| alternatives | |
| contraindications | | 1 | Hypersensitivity to pantoprazole or other PPIs | | 2 | Known history of severe allergic reactions to this or similar drugs |
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| interactions | | 1 | Drugs that are metabolized by the liver (e.g., certain anti-coagulants). | | 2 | Some medications used to treat HIV infection | | 3 | Atazanavir, and other drugs that require the CYP2C19 pathway for metabolism | | 4 | Caution is advised with concomitant use of warfarin. |
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| warnings and precautions | | 1 | Long-term use may increase the risk of fractures, especially in older patients and those with osteoporosis. | | 2 | Patients with a history of severe liver disease should use with caution and under strict medical supervision. | | 3 | May mask symptoms of other conditions. Do not discontinue treatment abruptly without consulting a doctor. | | 4 | Avoid concurrent use with certain drugs which could lead to severe interactions. |
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| additional informations | Consult a doctor before using pantoprazole, especially if you have any underlying health conditions. Report any unusual side effects to your physician immediately. |
| patient details | |
