| name | Differin Gel (adapalene) |
| classification | Topical retinoid |
| pharmacokinetics | Adapalene is a topical medication primarily absorbed into the skin with minimal systemic absorption. Pharmacokinetic details vary by individual and application. |
| suggested dosage | For acne vulgaris, typically apply 0.1% adapalene gel once daily, in the evening, to affected areas. Consult a dermatologist for personalized recommendations. |
| indications | Treatment of acne vulgaris, including comedones (blackheads/whiteheads), inflammatory lesions (papules/pustules), and mild to moderate acne. May help reduce scar appearance in some cases. |
| safety in pregnancy | Adapalene is generally not recommended during pregnancy unless benefits outweigh potential risks. Consult a healthcare provider. |
| safety in breastfeeding | Limited data exist regarding adapalene safety in breastfeeding. If used, avoid breastmilk for a period after application. Consult a healthcare professional. |
| side effects | | 1 | Skin irritation (erythema, dryness, peeling) | | 2 | Burning sensation | | 3 | Pruritus (itching) | | 4 | Skin redness | | 5 | Transient stinging | | 6 | Temporary photosensitivity |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity/allergy to adapalene or other retinoids | | 2 | Open/broken skin lesions in treatment area | | 3 | Severe skin conditions (e.g., eczema, psoriasis) | | 4 | Recent skin surgeries/procedures in treatment area |
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| interactions | | 1 | Potential interactions with other topical medications applied to the same area. Do not use other topical products simultaneously unless directed by a dermatologist. | | 2 | Some medications (e.g., certain antibiotics, diuretics) may increase sun sensitivity risk. |
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| warnings and precautions | | 1 | Avoid prolonged sun exposure. Use sunscreen with high SPF. | | 2 | Gradually increase application frequency/duration to minimize irritation. Consult dermatologist if irritation persists. | | 3 | Discontinue use and consult a physician if serious skin reactions occur. | | 4 | Not for use in children under 12 unless directed by a physician. |
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| additional informations | | 1 | Differin may increase absorption of other topically applied medications. | | 2 | Apply a thin layer to affected area, avoiding eyes and mouth. | | 3 | Treatment efficacy varies; consistent use is key. |
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| important disclaimer | This information is for educational purposes only and does not constitute medical advice. Always consult a dermatologist or other qualified healthcare professional for diagnosis and treatment of any medical condition. Do not self-treat. |
