| name | Differin (adapalene) |
| classification | Topical retinoid |
| pharmacokinetics | Adapalene is a topical medication absorbed into the skin, with very low systemic absorption. Primarily metabolized by the liver, metabolites are excreted in urine and bile. Absorption and metabolism can vary between individuals, but these variations are generally not clinically significant. |
| suggested dosage | Typical starting dose for acne vulgaris is 0.1% topical solution applied once daily at night to affected areas. A dermatologist may adjust dosage based on acne severity and individual response. Available as a gel, cream, or solution, potentially in prescription strengths. |
| indications | Differin is primarily used to treat mild to moderate acne vulgaris by reducing inflammation, sebum production, and comedones (blackheads/whiteheads). |
| safety in pregnancy | Differin is generally not recommended during pregnancy. Use during pregnancy should be carefully considered by a physician, weighing potential benefits against risks to the fetus. Individual patient factors and potential fetal exposure should be taken into account. |
| safety in breastfeeding | Limited information on Differin safety during breastfeeding exists. Avoid use during breastfeeding to minimize potential infant exposure. Consult your physician regarding the potential benefits and risks of use versus breastfeeding. |
| side effects | | 1 | Skin irritation (redness, dryness, peeling, burning, stinging) | | 2 | Skin dryness | | 3 | Increased sun sensitivity (especially initially) | | 4 | Papules | | 5 | Pustules | | 6 | Erythema | | 7 | Transient skin hyperpigmentation |
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| alternatives | |
| contraindications | | 1 | Hypersensitivity to adapalene or its components | | 2 | Severe skin disorders |
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| interactions | Limited significant drug interactions have been reported. Discuss all medications with your doctor. |
| warnings and precautions | | 1 | Apply only to affected skin areas. | | 2 | Gradually increase application area if needed. | | 3 | Avoid sun/UV exposure, especially at treatment initiation. | | 4 | Reduce application frequency if irritation occurs and notify your physician. | | 5 | Do not use on broken or damaged skin. | | 6 | Avoid harsh scrubs or abrasive products. |
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| additional information | Differin is sometimes used in combination with other acne treatments, such as benzoyl peroxide, based on individual patient needs. |
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