| name | Adapalene |
| classification | Retinoid, Topical |
| pharmacokinetics | Adapalene is a topical retinoid that is primarily metabolized by the liver. Absorption through the skin is low. It is not significantly metabolized in the liver. The primary metabolite is 4-hydroxyadapalene, which is also active. The drug is eliminated via the hepatic and biliary routes. |
| suggested dosage | Topical application once daily in the evening. Typical use is 0.1% cream or gel. Consult a dermatologist for specific dosage and duration recommendations based on individual needs. Lower concentrations may be used initially, and if tolerated, the concentration can be gradually increased. |
| indications | Acne vulgaris, specifically comedonal acne (blackheads and whiteheads). May be used for mild to moderate acne. |
| safety in pregnancy | Category C. Adapalene is not recommended for use during pregnancy unless the potential benefit outweighs the potential risk. Limited data are available regarding its use in pregnancy. It's crucial to carefully weigh the pros and cons with your healthcare provider, particularly in the first trimester. |
| safety in breastfeeding | Limited data are available regarding the safety of adapalene use during breastfeeding. It's advised to avoid use during breastfeeding unless the potential benefit outweighs any potential risk to the infant. Consult your healthcare provider before using this drug while breastfeeding. |
| side effects | | 1 | Skin irritation (redness, dryness, peeling, scaling) | | 2 | Burning sensation | | 3 | Stinging | | 4 | Pruritus (itching) | | 5 | Transient acne-like eruptions (in the initial phase of use) | | 6 | Erythema (redness of the skin) | | 7 | Exacerbation of pre-existing skin conditions | | 8 | Contact dermatitis | | 9 | Rarely, severe skin reactions |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity or allergy to adapalene or other retinoids | | 2 | Active skin infections or inflammatory skin conditions (like severe eczema or psoriasis) at the application site | | 3 | Severe skin damage or irritation at the application site |
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| interactions | Limited drug interactions are known. Adapalene's primary interactions are with other topical medications. If you are using other topical treatments, inform your doctor. Avoid use with strong exfoliants or other irritants. |
| warnings and precautions | | 1 | Avoid sun exposure, or use sunscreen with SPF 30 or higher when using topical adapalene | | 2 | Use a moisturizing cream or lotion to minimize skin dryness. | | 3 | Start with a low concentration and gradually increase if tolerated, to avoid severe irritation | | 4 | Do not use on broken or irritated skin | | 5 | Do not use with strong exfoliating agents | | 6 | Discontinue use and contact your healthcare provider if severe skin reactions develop. |
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| additional informations | | 1 | Apply a small amount of medication to the affected area(s), and gently massage it into the skin. | | 2 | Use only as directed. Do not increase the dosage without consulting a doctor | | 3 | Avoid use in the eyes or mucous membranes | | 4 | Proper skin hygiene and a healthy diet can be complimentary to treatment | | 5 | Results may take several weeks to appear | | 6 | Consistent application is key to achieving results |
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| patient specific considerations | | age | 25 years - No specific concerns for this age range | | weight | 70 kg - No specific concerns for this weight range |
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