| name | Tazarotene (Tazorac) |
| classification | Retinoid |
| pharmacokinetics | | absorption | Tazarotene is absorbed through the skin, with variable systemic absorption. | | distribution | Concentrates in the epidermis and sebaceous glands. | | metabolism | Metabolized primarily in the liver. | | excretion | Excreted primarily in the feces. |
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| suggested dosage | | adults | Topical application of a 0.05% or 0.1% cream or gel once daily in the evening. Specific dosing may vary based on individual response and the severity of the condition. | | notes | Dosage should be individualized. Avoid application to large areas of skin at once. |
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| indications | | 1 | Treatment of acne vulgaris | | 2 | Treatment of psoriasis | | 3 | Treatment of other dermatologic conditions involving thickened skin |
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| safety in pregnancy | Category C. Tazarotene should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. |
| safety in breastfeeding | Not recommended. Tazarotene may be present in breast milk and can potentially affect the nursing infant. |
| side effects | | 1 | Skin irritation (e.g., redness, dryness, burning, itching, scaling) | | 2 | Skin reactions (e.g., papules, pustules, vesicles) | | 3 | Photosensitivity | | 4 | Other potential side effects include but are not limited to: eye irritation, skin infection, or allergic reactions. Serious reactions are rare. |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to tazarotene or any of its components | | 2 | Open skin wounds or lesions in the treatment area | | 3 | Skin conditions that worsen with retinoids |
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| interactions | | 1 | Use with other topical retinoids, or with other medications that can cause skin irritation or photosensitivity is best avoided. Check with the prescribing physician if additional medications are used. |
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| warnings and precautions | | 1 | Apply a thin layer to the affected areas only. Avoid contact with eyes, mucous membranes, or other sensitive areas. Do not use on damaged or broken skin. | | 2 | Avoid sun exposure, use sunscreen, and wear protective clothing when using tazarotene topically as it can increase sun sensitivity. | | 3 | Discontinue if signs of irritation worsen or persist. | | 4 | Monitor for signs of potential allergic reactions. |
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| additional information | | 1 | Patients should be informed of the potential for skin irritation, redness and dryness. Patients must be monitored for these responses. It may take several weeks for the medication to become effective. Use only as directed by a physician. Store at room temperature and avoid moisture or excessive heat. Important: Always follow the instructions provided by your healthcare provider. | | 2 | For a 25-year-old male weighing 70 kg, the typical dosage and application would be similar to that described for adults. It is important to follow the instructions provided by the prescribing physician. |
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