| name | Adapalene Topical |
| classification | Retinoid, Topical Keratolytic |
| pharmacokinetics | Adapalene is a topical retinoid that is primarily absorbed locally by the skin. Limited systemic absorption occurs, but it is not significant. Metabolism occurs primarily via cytochrome P450 enzymes in the liver. Excretion is primarily through the biliary and urinary pathways. Significant accumulation does not occur after topical application. |
| suggested dosage | | adult | | general | A 0.1% adapalene cream or gel is typically used once daily at bedtime. Specific dosages and schedules are determined based on the patient's individual condition. Consult a healthcare professional for personalized recommendations. |
| | patient specific | Specific dosage will be determined by a doctor and adjusted as necessary by the doctor. |
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| indications | Adapalene is indicated for the treatment of mild to moderate acne vulgaris, characterized by comedones (blackheads and whiteheads), papules, and pustules. It can also be used in the management of comedonal acne. |
| safety in pregnancy | Adapalene is considered pregnancy category C. Limited data exists on the effects of adapalene on pregnant women, therefore, the potential risks and benefits must be carefully weighed by the healthcare provider. Adapalene use during pregnancy is not recommended unless clearly needed. |
| safety in breastfeeding | It is unknown whether adapalene is excreted in breast milk. Therefore, use during breastfeeding is not recommended. |
| side effects | | 1 | Skin irritation (e.g., redness, dryness, peeling, burning, itching) | | 2 | Skin inflammation (e.g., erythema, eczema-like reactions) | | 3 | Exacerbation of existing skin conditions | | 4 | Transient hyperpigmentation (darkening of the skin) | | 5 | Local skin reactions such as contact dermatitis | | 6 | Rarely: Systemic effects (e.g., headache, fatigue) | | 7 | Rarely: Skin cancer (though this is not directly linked to this medication; it is important to note the risk of skin cancer in patients with acne). |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to adapalene or other retinoids | | 2 | Severe skin conditions (e.g., severe eczema, psoriasis) | | 3 | Use in patients with active skin infections | | 4 | Use in individuals with open skin lesions that are being treated or at the site of an open wound |
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| interactions | Adapalene may increase the skin's sensitivity to sunlight. Use of sunscreen is recommended. Potential interactions with other topical medications should be discussed with the prescribing physician. |
| warnings and precautions | | 1 | Apply a small amount to the affected areas of the skin and use as directed by the doctor | | 2 | Start with a low frequency of use (e.g., every other day) and gradually increase to once daily if tolerated | | 3 | Avoid contact with the eyes and mucous membranes | | 4 | Discontinue use if significant irritation or adverse reactions occur. | | 5 | Inform the prescribing physician of any other medications, including over-the-counter and herbal preparations being taken. |
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| additional informations | Adapalene should be applied to the affected skin area(s) at night and patients should wash the area thoroughly with warm water before applying. |
| patient age | 25 years |
| patient weight | 70 kg |
