| name | Tretinoin |
| classification | Topical Retinoid |
| pharmacokinetics | Tretinoin is a topical retinoid that is readily absorbed into the skin. It is metabolized in the liver and excreted in the urine and bile. The absorption and metabolism are highly variable and influenced by individual factors like skin conditions and concomitant medications. |
| suggested dosage | | details | Dosage varies depending on the formulation and the individual's response. A common starting dose is 0.025% to 0.05% cream or gel once daily in the evening. The concentration may be increased gradually, and patients should be monitored for irritation or adverse effects. Consult a dermatologist for appropriate dosage. | | patient specific | For a 25-year-old male weighing 70 kg, a starting dose of 0.025% cream or gel applied topically once daily is typically appropriate. The physician should adjust the dose and frequency based on clinical response and any observed adverse effects. | | units | Percent (%) cream or gel, applied topically |
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| indications | | 1 | Acne vulgaris | | 2 | Photoaging | | 3 | Actinic keratosis | | 4 | Sun-induced skin damage | | 5 | Hyperpigmentation |
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| safety in pregnancy | Tretinoin is **not recommended** during pregnancy due to potential teratogenic effects. It may cause birth defects and should be avoided in women of childbearing potential unless the potential benefits outweigh the risks. |
| safety in breastfeeding | Tretinoin is **not recommended** during breastfeeding. It may be passed into breast milk, and the potential effects on the infant are unknown. |
| side effects | | 1 | Skin irritation (erythema, dryness, scaling, burning, itching) | | 2 | Photosensitivity (increased sun sensitivity): Patients should use sun protection measures | | 3 | Local skin reactions | | 4 | Transient increase in acne (in some patients), especially when initial therapy is started |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to tretinoin or other retinoids | | 2 | Active skin infections or lesions in the treatment area | | 3 | Severe skin conditions | | 4 | Severe skin irritation or inflammation at the application site |
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| interactions | Certain medications, such as topical or oral retinoids, antibiotics, and sunscreens, may interact with tretinoin. Consult the prescribing physician. |
| warnings and precautions | | 1 | Apply only to the affected area. | | 2 | Avoid applying to broken or irritated skin. | | 3 | Start with a low concentration and gradually increase if tolerated. | | 4 | Use sunscreen or sun protection when using tretinoin, particularly during the daytime. | | 5 | Patients should be monitored for skin reactions and the treatment should be discontinued if severe irritation develops. | | 6 | Inform your physician about other medications you are taking. |
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| additional informations | | 1 | Tretinoin is most effective when used consistently. | | 2 | Results may take several weeks or months to see. | | 3 | This information is not a substitute for professional medical advice. Always consult your physician or dermatologist before starting any new treatment. |
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