| drug | Polymyxin B Topical |
| name | Polymyxin B Sulfate Topical |
| classification | Antibiotic (Aminoglycoside) |
| pharmacokinetics | Topical application results in minimal systemic absorption. The drug primarily acts locally at the site of application. Little data is available on detailed pharmacokinetics in the specific context of a 25-year-old male weighing 70kg due to the primarily topical nature and minimal systemic absorption. |
| suggested dosage | Dosage is determined by the specific infection and severity. Consult a physician for appropriate dosage and duration of therapy. Usually applied topically as a cream or ointment. |
| indications | Topical Polymyxin B is indicated for the treatment of superficial skin infections caused by susceptible Gram-negative bacteria. Examples include infections like impetigo (staph and strep) or wound infections. *Note that this medication does not address viral infections like cold sores.* |
| safety in pregnancy | Limited data exists on the use of topical Polymyxin B during pregnancy. Consult with a physician regarding potential risks and benefits. |
| safety in breastfeeding | Limited data exists regarding the use of topical Polymyxin B during breastfeeding. Consult with a physician regarding potential risks and benefits. |
| side effects | | 1 | Local irritation (e.g., redness, burning, itching, rash) | | 2 | Allergic reactions (e.g., skin rash, hives, swelling) | | 3 | Contact dermatitis in some individuals |
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| alternatives | | 1 | | alternative drug | Bacitracin | | notes | Also a topical antibiotic, active against gram-positive bacteria. |
| | 2 | | alternative drug | Neomycin | | notes | Another topical antibiotic, active against gram-positive and some gram-negative bacteria. |
| | 3 | | alternative drug | Mupirocin | | notes | Effective against various Gram-positive bacteria, may be a suitable alternative depending on the specific infection. |
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| contraindications | | 1 | Hypersensitivity to polymyxin B or any of the inactive ingredients. | | 2 | Known allergic reaction to aminoglycosides. |
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| interactions | Limited interactions are expected with topical use. Consult with a physician regarding any other medications the patient is taking. |
| warnings and precautions | | 1 | Avoid contact with eyes. If contact occurs, flush immediately with water. | | 2 | Discontinue use if signs of skin irritation worsen or persist. | | 3 | Do not use on large or deep wounds. May not be appropriate for systemic infections. | | 4 | Use only as directed and avoid self-treatment. |
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| additional informations | | 1 | Consult a physician to determine appropriate treatment for your condition. | | 2 | This information is for educational purposes only and does not constitute medical advice. | | 3 | Always follow the instructions given by your prescribing physician or pharmacist regarding dosage and duration of therapy. |
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