| name | Piperazine |
| Classification | Antihelminthic (Anthelmintic) |
| Pharmacokinetics | Piperazine is rapidly absorbed from the gastrointestinal tract. It is primarily distributed to the intestines and to some extent the central nervous system. It is metabolized and excreted through the kidneys. Exact pharmacokinetic parameters (e.g., half-life, volume of distribution) can vary depending on the specific formulation and route of administration. The rate of absorption and excretion may also be affected by concomitant medications or conditions like renal insufficiency. |
| suggested dosage | Dosage for piperazine varies depending on the specific indication (e.g., roundworms vs. pinworms). Important to consult a physician for precise dosage recommendations. Dosage is typically based on weight and age and given in divided doses. |
| indications | | 1 | Treatment of roundworm (ascariasis) infections. | | 2 | Treatment of pinworm (enterobiasis) infections. |
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| Safety in pregnancy | Piperazine is generally considered to be safe during pregnancy, although it's not been studied extensively in human pregnancies. However, it may be associated with adverse reactions. Consult a physician. |
| Safety in breastfeeding | Limited data exists concerning piperazine use in breastfeeding mothers. Potential risks to the infant are uncertain. Do not use without discussing with your doctor. |
| side effects | | 1 | Gastrointestinal disturbances (e.g., nausea, vomiting, abdominal cramps, diarrhea). | | 2 | Headache. | | 3 | Drowsiness and dizziness. | | 4 | Skin reactions (e.g., rash). | | 5 | Allergic reactions (e.g., hives, anaphylaxis) | | 6 | Neurological effects (seizures in rare cases, particularly in children, high doses, or pre-existing conditions). | | 7 | Liver dysfunction |
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| alternatives | |
| contraindications | | 1 | Severe liver disease. | | 2 | Known hypersensitivity or allergic reactions to piperazine or other related drugs. | | 3 | Severe renal impairment. | | 4 | History of seizures or neurological disorders. |
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| interactions | | 1 | The use of piperazine along with other medications may affect its absorption and metabolism or increase the risk of side effects. Consult your doctor before taking any other medications while on piperazine. | | 2 | Some medications may alter the way the body metabolizes piperazine. Your doctor can assess if there are potential interactions. |
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| warnings and precautions | | 1 | Close monitoring of liver function is important during treatment, especially in those with underlying liver disease or if high doses are required. | | 2 | Children should be carefully monitored for potential adverse effects of piperazine. | | 3 | Patients with pre-existing neurological conditions should be especially cautious in the use of piperazine, as it may exacerbate pre-existing conditions. | | 4 | If side effects like drowsiness, dizziness, or seizures appear, consult with your physician immediately. |
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| additional informations | | 1 | Piperazine is available in different formulations (e.g., tablets, syrups) for oral administration. | | 2 | Appropriate diagnostic testing (e.g., stool examination) should be performed before initiating piperazine treatment to confirm the presence and type of infection. |
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| patient specific considerations | | age | 25 years | | weight | 70 kg | | general notes | Dosage and safety considerations for piperazine in a healthy 25-year-old, 70 kg male are generally similar to that for other age groups and weights but specific details are to be confirmed with a physician. |
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