| name | PEG (Polyethylene Glycol) |
| classification | Osmotic laxative |
| pharmacokinetics | PEG is primarily excreted unchanged in the stool. Absorption is minimal. The duration of action is generally several hours, depending on the specific PEG formulation and dosage. The effect is primarily related to the osmotic pull of the PEG molecules which draw water into the stool. |
| suggested dosage | Dosage varies significantly depending on the specific PEG formulation and intended use. It is crucial to follow the instructions on the package insert or as directed by a healthcare professional. Commonly available formulations in the US include PEG 3350 and PEG/ electrolytes, and dosages range from 17g to 30g depending on the formulation. |
| indications | PEG is primarily used for the treatment of constipation, particularly for preparing the bowel for medical procedures like colonoscopy. It can also be used for the management of fecal impaction. |
| safety in pregnancy | Limited data on the safety of PEG in pregnant women are available. If PEG is considered necessary during pregnancy, the potential benefits should be weighed against potential risks. Consultation with a healthcare provider is strongly advised. The risk may vary by formulation and dosage. |
| safety in breastfeeding | PEG is generally considered safe to use during breastfeeding, as it's not absorbed systemically in significant amounts. However, as with any medication, a discussion with your healthcare provider is recommended. |
| side effects | Common side effects may include bloating, cramping, abdominal discomfort, and diarrhea. These are typically mild and self-limiting. More severe, though less common, side effects may include electrolyte imbalances (especially if PEG electrolyte products are used) and dehydration. If any serious side effects occur, discontinue use and consult a doctor immediately. |
| alternatives | |
| contraindications | Individuals with known hypersensitivity or allergic reactions to PEG should avoid its use. Caution is warranted in patients with significant dehydration or electrolyte abnormalities, as well as those with severe bowel disorders. PEG should be used with caution if the patient has a suspected bowel obstruction or perforation |
| interactions | While PEG is not known to have significant drug interactions, there may be potential interactions with medications that affect electrolyte balance. It is important to inform your doctor about all medications and supplements you are taking. |
| warnings and precautions | If constipation persists despite using PEG, consult a doctor. Ensure adequate fluid intake when taking PEG to prevent dehydration. PEG should not be used in individuals with known severe bowel disorders. |
| additional information | PEG formulations come in different osmolar concentrations and electrolytes. Specific instructions for administration, including dosage and frequency should always be followed and discussed with a medical professional. Consult your doctor or pharmacist for specific guidance related to individual circumstances. Dosage may need to be adjusted based on individual needs, medical history, and clinical response. |
| patient specific considerations | For a 25-year-old male weighing 70kg, the specific dosage will vary based on the reason for use. Detailed consultation with a medical professional is necessary to determine appropriate dosage and safety measures. |
| other important fields | |
