| name | Lincosamides |
| Classification | Antibiotics |
| Pharmacokinetics | Lincosamides are primarily bacteriostatic, inhibiting protein synthesis in susceptible bacteria. They are well absorbed orally, but variable absorption can occur. Distribution is relatively broad, including tissues like lungs, bone, and skin. Metabolism is primarily hepatic, and excretion is primarily renal. There can be accumulation in patients with renal impairment. The half-life varies depending on the specific lincosamide. |
| suggested dosage | | note | Dosage varies significantly based on the specific lincosamide (e.g., clindamycin, lincomycin) and the indication. Consult with a healthcare professional for appropriate dosage. | | examples | | 1 | | lincosamide | Clindamycin | | dosage | 150-450 mg every 6 hours orally or intravenously |
| | 2 | | lincosamide | Lincomycin | | dosage | 500 mg every 6 hours orally or intravenously |
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| indications | Lincosamides are used to treat a range of bacterial infections, including skin infections, respiratory tract infections, and soft tissue infections. They are particularly effective against certain anaerobic bacteria. |
| safety in pregnancy | Lincosamides can be used during pregnancy, but use should be carefully considered and only under the direction of a healthcare professional. Potential risks and benefits should be evaluated. Limited data for some lincosamides exists. Avoid using in late pregnancy if possible. |
| safety in breastfeeding | Lincosamides are secreted in breast milk. Use during breastfeeding should only occur after careful assessment of potential benefits and risks to the infant. Use should be avoided or substituted with alternative antibiotics where possible. |
| side effects | | 1 | Diarrhea | | 2 | Nausea | | 3 | Vomiting | | 4 | Abdominal pain | | 5 | Stomach upset | | 6 | Superinfections (e.g., yeast infections) | | 7 | Pseudomembranous colitis (severe) | | 8 | Hepatitis | | 9 | Skin rash | | 10 | Allergic reactions | | 11 | Stevens-Johnson syndrome (rare but severe) |
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| contraindications | | 1 | Hypersensitivity to lincosamides | | 2 | History of Clostridium difficile colitis | | 3 | Severe liver disease | | 4 | Concurrent use with certain medications (e.g., medications that alter the gut flora) |
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| interactions | Lincosamides may interact with other medications, particularly those affecting hepatic or renal function. Consult with a healthcare professional regarding any concurrent medications. |
| warnings and precautions | Patients with pre-existing kidney or liver disease may require dosage adjustments. Monitor for signs of colitis or other superinfections. Patients with a history of severe allergic reactions should be carefully monitored. |
| additional informations | The specific lincosamide and its dosage form can influence the pharmacokinetic profile and possible side effects. Always refer to the prescribing information for specific lincosamides. |
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