| name | Fluticasone Furoate |
| Classification | Corticosteroid, inhaled |
| Pharmacokinetics | Fluticasone furoate is a potent corticosteroid that is primarily metabolized in the liver. Following inhalation, a significant portion of the drug is deposited in the oropharynx and swallowed, leading to first-pass hepatic metabolism. A smaller fraction reaches the lungs. The bioavailability of inhaled fluticasone is therefore relatively low compared to systemic corticosteroids. The drug's duration of action is related to its relatively slow clearance from the lung tissue. |
| suggested dosage | | adult male 25 70kg | | 1 | | indication | Asthma | | dosage | Initial dose: 100-250 mcg twice daily. Dosage may be adjusted based on patient response and tolerance. Maintenance dose should be at the lowest effective dose that controls symptoms. |
| | 2 | | indication | Allergic rhinitis | | dosage | Initial dose: 50-250 mcg twice daily. Titrate as needed. Lower doses may be appropriate based on symptoms. |
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| | important notes | Dosage should be individualized based on clinical response. Consult with a physician for appropriate dosage adjustments. |
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| indications | | 1 | Treatment of asthma | | 2 | Treatment of allergic rhinitis (e.g., seasonal allergies) | | 3 | Prevention and treatment of COPD exacerbations. |
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| Safety in pregnancy | Limited data exists on the safety of fluticasone furoate in pregnancy. It is generally not recommended for use during pregnancy unless the potential benefits outweigh the potential risks. Consult with a healthcare provider to discuss the risks and benefits. |
| Safety in breastfeeding | Fluticasone furoate may be present in breast milk. While generally considered safe in breastfeeding mothers, it is advised to consult a healthcare provider to assess the risk-benefit ratio based on the individual clinical situation. |
| side effects | | 1 | Oral candidiasis (thrush) | | 2 | Hoarseness | | 3 | Cough | | 4 | Headache | | 5 | Nasal irritation | | 6 | Dysphonia | | 7 | Fatigue | | 8 | Sore throat | | 9 | Pharyngitis | | 10 | Hypertension | | 11 | Increased appetite | | 12 | Insomnia | | 13 | Nausea | | 14 | Back pain | | 15 | Adverse effects on bone density, rarely in long-term use | | 16 | Important Note: While rare, adrenal suppression can occur with high-dose, long-term systemic corticosteroid therapy. Inhaled fluticasone, while associated with systemic absorption, does not typically cause significant systemic effects. |
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| alternatives | |
| contraindications | | 1 | Hypersensitivity to fluticasone furoate or other components of the formulation | | 2 | Uncontrolled systemic infections |
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| interactions | Limited interactions have been reported. Potential interactions may occur with other corticosteroids and medications that affect the hypothalamic-pituitary-adrenal (HPA) axis. Consult with a physician to check for any potential drug interactions. |
| warnings and precautions | | 1 | Patients with a history of glaucoma should use with caution. | | 2 | Patients with a history of infections should discuss with a physician to ensure that any infections are controlled. | | 3 | Monitor for signs of adrenal insufficiency, particularly if doses are high or the patient has a history of adrenal insufficiency. | | 4 | Proper technique for inhalation is crucial to maximize efficacy and minimize side effects. Patients should be adequately instructed in the use of the inhaler. |
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| additional informations | Patients should be monitored closely for response to therapy and potential adverse effects. Regular follow-up appointments with a physician are necessary. |
