| name | Budesonide |
| classification | Glucocorticoid; inhaled corticosteroid |
| pharmacokinetics | Budesonide is rapidly absorbed from the lungs. It is predominantly metabolized in the liver, with minimal systemic absorption compared to other inhaled corticosteroids. The first-pass effect in the lung and liver significantly reduces systemic exposure, minimizing potential side effects. Its half-life is relatively short, allowing for quick adjustments to dosage. Excretion is primarily through the bile. |
| suggested dosage | | notes | Dosage should be individualized based on the patient's condition and response. The following is a general guideline and should be determined in consultation with a physician. | | adult | | asthma | Typically 200-800 mcg/day in divided doses, depending on severity. Higher doses may be used in severe asthma. | | COPD | Generally 200-800 mcg/day in divided doses. Starting dose often lower and titrated upward as needed. |
| | specific details | Consult the product information leaflet for the exact dosage recommendations for the specific formulation of budesonide you are considering. |
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| indications | Budesonide is primarily used in the management of asthma and chronic obstructive pulmonary disease (COPD). It's also used for some inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis (though different formulations and routes of administration are used in these cases compared to asthma/COPD). |
| safety pregnancy | Budesonide is generally considered safe for use during pregnancy, but it's essential to weigh the potential risks and benefits. Consult with your doctor. The use during pregnancy is generally only recommended when the potential benefits outweigh the risks. It is not recommended in uncontrolled or severe asthma situations. Close monitoring is essential. |
| safety breastfeeding | Limited data exists on budesonide's excretion in breast milk, but in general inhaled budesonide is considered to pose a low risk to a nursing infant. If used during breastfeeding, it is important to discuss with your doctor to weigh the risks and benefits, and to monitor your infant for any signs of adverse reactions. |
| side effects | | 1 | Cough | | 2 | Hoarseness | | 3 | Oral candidiasis (thrush) | | 4 | Dysphonia (difficulty speaking) | | 5 | Headache | | 6 | Nasal irritation | | 7 | Pharyngitis | | 8 | Upper respiratory tract infections | | 9 | Nausea | | 10 | Vomiting | | 11 | Abdominal pain | | 12 | Changes in appetite | | 13 | Weight gain | | 14 | Facial swelling or puffiness | | 15 | Fatigue | | 16 | Mood swings |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity or allergy to budesonide or other components of the medication. | | 2 | Active untreated systemic fungal infections. |
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| interactions | Budesonide may interact with other medications, especially those affecting liver function or the immune system. Consult with your doctor or pharmacist before taking any other medications, especially other corticosteroids. |
| warnings precautions | | 1 | Use cautiously in patients with impaired liver function or kidney disease. | | 2 | Monitor for signs of adrenal suppression, particularly if used at high doses or for extended periods. | | 3 | Do not abruptly discontinue use; gradual tapering under medical supervision is essential. | | 4 | May increase susceptibility to infections. | | 5 | Risk of osteoporosis is possible with long-term use, especially in post-menopausal women, or those with other risk factors for osteoporosis. |
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| additional informations | Different formulations of budesonide (e.g., inhaled, oral) have different pharmacokinetic profiles. Always use the formulation and dosage prescribed by your doctor. |
| patient profile | |
