| name | Tretinoin |
| Classification | Comedolytic agent, retinoid |
| Pharmacokinetics | Tretinoin is readily absorbed through the skin. The major metabolite, retinoic acid, is thought to be the active form. It is metabolized by the liver and excreted primarily in the urine. Absorption and metabolism may vary between individuals. |
| suggested dosage | Topical application, typically starting with a very low concentration (0.025%) once daily in the evening, gradually increasing to 0.05% or 0.1% as tolerated. Specific dosage depends on individual response and tolerability. |
| indications | Treatment of acne vulgaris, including comedones (blackheads and whiteheads), papules, and pustules. May also be used for certain types of psoriasis and other skin conditions. |
| safety in pregnancy | Category X. Tretinoin is absolutely contraindicated during pregnancy. It should not be used by women of childbearing potential unless appropriate precautions are taken to avoid pregnancy. |
| safety in breastfeeding | It is not recommended to use Tretinoin during breastfeeding due to potential for absorption and transfer into breast milk. Consult a healthcare professional for alternative options. |
| side effects | | 1 | Skin irritation (redness, dryness, burning, scaling, peeling), | | 2 | Increased sun sensitivity (wear sunscreen and avoid sun exposure during peak hours). | | 3 | Erythema | | 4 | Pruritus | | 5 | Pain | | 6 | Exacerbation of pre-existing skin conditions | | 7 | Rarely, allergic reactions |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to retinoids or other ingredients in the formulation | | 2 | Active skin infections or inflammation at the application site | | 3 | Severe skin conditions | | 4 | Pregnancy | | 5 | Lactation (breastfeeding) |
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| interactions | | 1 | May increase the skin's sensitivity to sunlight; concurrent use of other photosensitizing agents should be avoided. | | 2 | Potentially increases the absorption of certain topically applied medications. | | 3 | Combination with strong topical or systemic comedolytic agents should be discussed with a doctor. |
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| warnings and precautions | | 1 | Start with a low concentration and gradually increase as tolerated to minimize irritation | | 2 | Use sunscreen with a high SPF regularly when using Tretinoin | | 3 | Inform your doctor about all other medications you are taking | | 4 | Avoid using other topical products on the same area of the skin at the same time, especially if they contain harsh or drying agents. | | 5 | Regular follow-up with your dermatologist is crucial to monitor treatment effectiveness and adjust dosage as needed. |
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| additional informations | | 1 | Application in the evening is often preferred due to the increased sun sensitivity | | 2 | Important to follow application instructions carefully | | 3 | Patient should be made aware of potential for temporary darkening of skin pigmentation in some individuals. |
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| patient specific details | |
