| name | Clotrimazole Topical |
| classification | Anti-fungal, azole derivative |
| pharmacokinetics | | absorption | Limited systemic absorption from topical application. Primarily acts locally. | | distribution | Concentrates in the skin and affected area. | | metabolism | Minimal hepatic metabolism. Primarily excreted unchanged in the urine. | | excretion | Primarily through the urine. |
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| suggested dosage | | adult | Apply a thin film to the affected area 1-2 times daily, or as directed by a physician. Treatment duration depends on the severity and type of infection. Ointments and creams may need to be applied more frequently, as needed. | | notes | Dosage is dependent on the specific infection type, severity, and the product's formulation. Consult a physician for specific instructions. |
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| indications | Superficial fungal infections of the skin, such as athlete's foot, ringworm, jock itch, and yeast infections (candidiasis). |
| safety in pregnancy | | category | Category C. Animal studies have shown adverse effects, but adequate and well-controlled studies in pregnant women are not available. Use only if the potential benefit justifies the potential risk to the fetus. | | notes | Consult a healthcare provider for guidance regarding use during pregnancy. |
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| safety in breastfeeding | | category | Data limited. Limited information exists about the effects of clotrimazole on the nursing infant. Use with caution, and consult a healthcare provider before use during breastfeeding. | | notes | Consult a healthcare provider for guidance regarding use during breastfeeding. |
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| side effects | | 1 | Local skin reactions such as irritation, burning, redness, and itching | | 2 | Allergic reactions (rare) | | 3 | Contact dermatitis in susceptible individuals |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity or allergy to clotrimazole or other azole antifungals | | 2 | Open wounds or skin lesions in the treatment area | | 3 | Use in a way that would result in significant contact with mucous membranes or eyes |
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| interactions | | 1 | Potentially with other topical medications or with concomitant systemic medication. Consult a physician regarding possible drug interactions. | | 2 | Certain antifungal agents may affect the liver. Check with physician if already on other medications that may affect liver function |
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| warnings and precautions | | 1 | Apply only to the affected area. Avoid contact with eyes and mucous membranes. | | 2 | Stop use and consult a doctor if the condition worsens or if symptoms persist for more than a few weeks. | | 3 | Do not use on large areas of skin unless directed by a physician. Possible systemic absorption might occur in larger applications. | | 4 | Do not use if the skin is broken or irritated | | 5 | Use only as directed. |
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| additional informations | Clotrimazole is effective against a broad spectrum of dermatophytes and yeasts. Its mechanism of action involves disrupting fungal cell membranes, leading to cell death. |
| patient profile | |
