| name | Clobetasol Propionate |
| classification | Topical corticosteroid, potent |
| pharmacokinetics | Clobetasol propionate is a potent corticosteroid that is primarily absorbed transdermally. Its absorption varies significantly based on the area treated, the thickness of the skin, and the duration of exposure. The drug is metabolized in the liver. Elimination occurs primarily through the liver and bile. Minimal systemic absorption occurs with topical application. |
| suggested dosage | **Important:** Dosage must be determined by a healthcare professional and is highly individualized. The following is *not* a substitute for medical advice.
* **For skin conditions:** A thin film of ointment or cream applied once daily to affected area(s). Do not exceed the recommended frequency or amount without consulting a doctor. |
| indications | Used topically to treat inflammatory skin conditions such as psoriasis, eczema, and other dermatological conditions involving inflammation. Can also be used in certain cases for the treatment of dermatoses and inflammatory skin conditions. |
| safety in pregnancy | Limited data available. While generally considered safe during pregnancy, topical use of clobetasol should only be prescribed by a healthcare professional with careful consideration of potential risks versus benefits. Systemic absorption is minimal, but potential effects on the fetus need to be weighed. |
| safety in breastfeeding | Minimal systemic absorption; however, it is not advisable to use this medication if breastfeeding. A doctor should be consulted before using any topical corticosteroid during breastfeeding. |
| side effects | | 1 | Local skin reactions (e.g., burning, stinging, irritation, skin atrophy, skin thinning, striae, telangiectasia) | | 2 | Systemic effects (rare with topical application but possible with extensive use): Cushing's syndrome-like symptoms (e.g., moon face, buffalo hump, weight gain), adrenal suppression, increased blood sugar | | 3 | Infection at the application site if the skin barrier is compromised |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to clobetasol propionate or any of its components | | 2 | Active or suspected skin infection at the application site | | 3 | Use over large areas of the body or prolonged use without medical supervision | | 4 | Use in infants under 2 months old in the majority of cases. Consult a healthcare provider. |
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| interactions | Limited drug interactions are anticipated with topical use. However, potential interactions exist with other systemic medications, particularly those affecting adrenal function. Always inform your physician about all medications you're taking, including over-the-counter medications and herbal supplements. |
| warnings | | 1 | Do not use on damaged or broken skin. | | 2 | Avoid contact with eyes, mouth, and mucous membranes. | | 3 | Do not use in the genital or perianal area unless prescribed by a physician. | | 4 | Do not use more often than prescribed, and do not exceed the prescribed area of treatment. | | 5 | Monitor for signs of worsening skin conditions. | | 6 | Stop use and consult physician if symptoms worsen or new symptoms develop. |
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| precautions | | 1 | Patients with a history of skin thinning or striae should use this medication with caution. | | 2 | Patients with diabetes or kidney disease need to exercise caution, as corticosteroid use can affect glucose and fluid balance. Consult your doctor regarding these considerations. | | 3 | Avoid prolonged use. Use only as prescribed by a healthcare provider. |
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| additional informations | The effectiveness and safety of clobetasol propionate are critically dependent on proper use and medical supervision. |
| patient profile | |
