| name | Cefpodoxime |
| Classification | Cephalosporin antibiotic, third-generation |
| Pharmacokinetics | Cefpodoxime is well absorbed orally, reaching peak serum concentrations within 1-2 hours. It is primarily excreted in the urine, mostly unchanged. The absorption and elimination may vary slightly depending on individual factors. The half-life is approximately 2 hours. It concentrates in some tissues, such as the lung, more than others. |
| suggested dosage | | adult | | mild to moderate infections | 200 mg PO once daily for 7-10 days. | | severe infections | 200-400 mg PO once daily for 7-14 days |
| | notes | Dosage adjustments may be needed based on individual factors and the severity of the infection. Always follow the prescription and consult with a healthcare provider for appropriate dosage recommendations. |
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| indications | Cefpodoxime is indicated for treating mild to moderate infections caused by susceptible bacteria, including infections of the respiratory tract, skin and skin structure infections, urinary tract infections, and some types of pelvic inflammatory disease. |
| safety in pregnancy | Limited data exists on cefpodoxime's safety during pregnancy. Use in pregnancy should be considered only if the potential benefit outweighs the potential risk. Consult a healthcare provider to discuss the risks and benefits of using cefpodoxime during pregnancy. |
| safety in breastfeeding | Cefpodoxime is excreted in breast milk in small amounts. The potential risk to the infant is likely low. However, it is best to discuss the use of cefpodoxime with a healthcare provider, weighing the risks versus the benefits to both the mother and child. |
| side effects | | 1 | Nausea | | 2 | Vomiting | | 3 | Diarrhea | | 4 | Abdominal pain | | 5 | Headache | | 6 | Skin rash | | 7 | Pruritus | | 8 | Hypersensitivity reactions (e.g., anaphylaxis, Stevens-Johnson Syndrome) | | 9 | Superinfection (e.g., candidiasis) | | 10 | Elevated liver enzymes |
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| alternatives | |
| contraindications | Patients with a known allergy to cephalosporins or other penicillin-related antibiotics should not receive cefpodoxime. |
| interactions | Cefpodoxime can interact with certain medications, such as oral contraceptives, anticoagulants, and other antibiotics. Consult a healthcare provider about possible drug interactions. |
| warnings and precautions | | 1 | Monitor for signs of allergic reactions (e.g., rash, difficulty breathing). | | 2 | Monitor for signs of superinfection (e.g., vaginal yeast infections). | | 3 | Use with caution in patients with renal impairment. Dosage adjustments might be required. | | 4 | Patients with a history of allergic reactions to penicillin should be carefully monitored during treatment with cephalosporins due to the potential for cross-reactivity. |
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| additional information | It's important to complete the full course of antibiotics, even if symptoms improve, to prevent the recurrence of infection and the development of resistant bacteria. Avoid alcohol during treatment to minimize the risk of side effects. The provided information is for educational purposes only and does not substitute professional medical advice. Always consult a healthcare provider for diagnosis and treatment. |
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