| name | Amoxicillin |
| classification | Penicillins, Beta-lactam antibiotics |
| pharmacokinetics | | absorption | Rapidly absorbed from the gastrointestinal tract. Bioavailability is high, typically around 80-90%. | | distribution | Distributes widely throughout the body, including the cerebrospinal fluid (CSF) when inflammation is present. | | metabolism | Primarily eliminated unchanged in the urine. | | excretion | The majority is excreted in the urine as unchanged drug. Renal impairment significantly affects clearance. |
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| suggested dosage | | adult | | oral | 250 mg-500 mg every 8 hours or 875 mg-1000 mg every 12 hours depending on the infection and severity. |
| | note | Dosage may vary based on individual needs and severity of infection. Consult with a healthcare provider for personalized dosage recommendations. Adjustments in dosage may be required for patients with renal impairment. | | patient specific consideration | For a 70 kg male, typical adult dosages are appropriate. However, precise dosage will depend on the infection being treated and renal function. Adjusting the dose based on kidney function is crucial. |
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| indications | Amoxicillin is used to treat bacterial infections caused by susceptible bacteria. Examples include infections of the ear, throat, respiratory tract, skin and soft tissues, urinary tract, and gonorrhea, among others. |
| safety in pregnancy | Amoxicillin is generally considered safe for use during pregnancy, but the use in early pregnancy and lactation requires careful consideration, and the benefit-risk ratio should be assessed by a healthcare professional. |
| safety in breastfeeding | Amoxicillin is excreted in breast milk in small amounts. Usually, the benefits of treatment generally outweigh the potential risks for the infant, but it is crucial to consult with the healthcare professional. |
| side effects | | 1 | Nausea | | 2 | Vomiting | | 3 | Diarrhea | | 4 | Abdominal pain | | 5 | Allergic reactions (rash, hives, itching, anaphylaxis) | | 6 | Superinfections (e.g., yeast infections) | | 7 | Headache |
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| alternatives | |
| contraindications | | 1 | Patients with known hypersensitivity or allergy to penicillin or other beta-lactam antibiotics. | | 2 | Severely impaired renal function. |
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| interactions | | 1 | Oral anticoagulants (warfarin) | | 2 | Probenecid | | 3 | Allopurinol | | 4 | Other drugs that may affect renal function |
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| warnings and precautions | | 1 | Monitor for signs of allergic reactions. If a reaction occurs, immediately discontinue the medication and seek medical attention. | | 2 | Monitor for and treat any signs of superinfections | | 3 | Important to complete the entire course of antibiotics as prescribed, even if symptoms improve. |
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| additional informations | | 1 | Amoxicillin is typically administered orally as a capsule or tablet. It is available in different dosages for varying needs. | | 2 | Always use Amoxicillin under the supervision of a physician. This information is not a substitute for professional medical advice. |
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