| name | Azelaic Acid (Finacea) |
| classification | Keratolytic, Anti-inflammatory, Antimicrobial |
| pharmacokinetics | | absorption | Azelaic acid is poorly absorbed from the skin, with minimal systemic effects. | | distribution | Limited distribution to other tissues. | | metabolism | Minimal first-pass metabolism. | | excretion | Primarily excreted in the urine, and some in the feces. |
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| suggested dosage | | adults | Apply a thin layer of cream or gel once daily or twice daily in the evening to affected skin areas. | | note | Dosage and frequency may be adjusted based on individual response and tolerance by a healthcare professional |
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| indications | | 1 | Treatment of moderate to severe inflammatory acne. | | 2 | Treatment of comedonal acne (blackheads and whiteheads). | | 3 | Treatment of rosacea | | 4 | Treatment of melasma |
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| safety in pregnancy | | classification | Category C. Limited human data. Consult a healthcare professional before using during pregnancy. | | details | Animal studies have shown some adverse effects. The potential risk to the developing fetus is unknown. |
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| safety in breastfeeding | | classification | Data is limited. Consult a healthcare professional before using. | | details | Azelaic acid is expected to be present in breast milk, but the impact on the infant is not fully known. If used, close monitoring of the infant is recommended. |
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| side effects | | 1 | Skin irritation (redness, dryness, burning, stinging). | | 2 | Skin pigmentation changes (discoloration, hyperpigmentation). | | 3 | Transient or mild inflammation (redness and swelling). | | 4 | Allergic reactions (rash, itching). |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity or allergy to azelaic acid or any of the components of the product. |
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| interactions | | 1 | No significant drug-drug interactions are known. | | 2 | May interact with other topical medications; inform your physician of all medications being used. |
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| warnings and precautions | | 1 | Use a sunscreen with SPF 30 or higher when using azelaic acid products to reduce the risk of sun sensitivity | | 2 | Avoid contact with eyes. If contact occurs, rinse thoroughly with water. | | 3 | If skin irritation is severe or persistent, discontinue use and consult a healthcare professional. | | 4 | May cause temporary skin lightening, which usually resolves after discontinuation. | | 5 | Patients with a history of skin conditions should consult their healthcare professional before use. |
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| additional information | | 1 | Azelaic acid can be applied at different frequencies. A healthcare professional will recommend the appropriate regimen. | | 2 | Optimal response to treatment may take several weeks. Do not stop using the medication unless instructed by your healthcare provider. |
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| patient profile | |
