| name | Tamsulosin |
| Classification | Alpha-1A adrenergic receptor antagonist |
| Pharmacokinetics | Tamsulosin is primarily metabolized in the liver. It is highly protein-bound (approximately 99%) and has a relatively long half-life (approximately 8-10 hours). Absorption is relatively slow and variable, with peak plasma concentrations occurring 2-5 hours after oral administration. Excretion is primarily via the kidneys. Important to note: Renal function may impact clearance. |
| suggested dosage | | adult | | typical | 0.4 mg once daily, taken orally with a glass of water preferably at the same time each day. Starting dose can be adjusted based on the patient response to treatment and adverse effects. | | max | 0.8 mg once daily | | notes | Dosage adjustments may be necessary in patients with renal impairment. Consult a healthcare provider for specific recommendations. |
| | patient specific | The dosage for a 25-year-old male weighing 70 kg should follow the standard adult dosage guidelines, unless otherwise advised by a doctor based on specific medical conditions or factors. It is essential to follow the prescribing doctor's recommendations strictly. |
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| indications | Tamsulosin is primarily used to treat benign prostatic hyperplasia (BPH). It helps relax the muscles in the prostate and the bladder neck, improving urine flow. |
| Safety in pregnancy | Tamsulosin is not recommended during pregnancy unless the potential benefits outweigh the potential risks. Animal studies have shown adverse effects; however, no adequate well-controlled studies have been conducted in pregnant women. Consult a healthcare provider for appropriate guidance. |
| Safety in breastfeeding | Tamsulosin is unlikely to be excreted in significant amounts into breast milk. However, it's best to consult a healthcare provider about the potential risks and benefits before using the medication while breastfeeding. |
| side effects | | 1 | Dizziness | | 2 | Headache | | 3 | Fatigue | | 4 | Nasal congestion | | 5 | Drowsiness | | 6 | Abnormal ejaculation | | 7 | Blurred vision | | 8 | Low blood pressure (orthostatic hypotension) | | 9 | Back pain | | 10 | Nausea | | 11 | Diarrhea | | 12 | Abdominal pain | | 13 | Priapism |
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| alternatives | |
| contraindications | | 1 | Hypersensitivity to tamsulosin or any of its components. | | 2 | Severe hepatic impairment. | | 3 | Patients with a known history of orthostatic hypotension. | | 4 | Patients with significant renal impairment (e.g., severe kidney disease) requiring dose adjustments. | | 5 | Patients with severe corneal impairment |
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| interactions | | 1 | Concomitant use with other medications that lower blood pressure may potentiate the risk of hypotension (e.g., antihypertensive drugs). | | 2 | Concurrent use with certain drugs that inhibit or induce hepatic CYP3A4 enzyme activity might alter tamsulosin's pharmacokinetics. | | 3 | Use caution in conjunction with medications known to potentially affect renal function or blood glucose levels. |
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| warnings and precautions | | 1 | Patients should be advised to monitor for signs of orthostatic hypotension, especially upon initial dosing and dosage adjustments. | | 2 | Use cautiously in patients with a history of cardiovascular disease (e.g., myocardial infarction, congestive heart failure). | | 3 | Careful monitoring of blood pressure is necessary, particularly in patients with renal dysfunction or hypertension. | | 4 | Monitor for priapism (prolonged erection) and seek immediate medical attention if experienced. |
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| additional informations | Tamsulosin should be taken at approximately the same time daily. If a dose is missed, take it as soon as possible. However, if it's almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not take a double dose. Consult with a healthcare provider before taking tamsulosin if you have any pre-existing medical conditions. |
| patient age | 25 years |
| patient weight | 70 kg |
