| name | Dutasteride |
| classification | 5α-Reductase inhibitor |
| pharmacokinetics | Dutasteride is well absorbed after oral administration. Peak plasma concentrations are typically reached within 1-2 hours. It is highly bound to plasma proteins (99%). The drug is metabolized extensively in the liver, primarily via the CYP3A4 pathway. The major active metabolite, t-dutasteride, has an extended half-life, contributing to a sustained effect. Elimination is primarily via the biliary route. |
| suggested dosage | | male 25 70kg | 0.5 mg orally once daily | | notes | This dosage is standard for benign prostatic hyperplasia (BPH) treatment. Always follow the prescribed dosage by your healthcare professional. |
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| indications | Treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss (androgenetic alopecia). |
| safety in pregnancy | Category X. **Absolutely contraindicated in pregnancy.** Women of childbearing potential should use effective contraception. Dutasteride is known to have a harmful effect on a developing male fetus. |
| safety in breastfeeding | Not recommended. Dutasteride is excreted into breast milk. |
| side effects | | 1 | Decreased libido, erectile dysfunction, ejaculation disorders | | 2 | Breast tenderness or enlargement | | 3 | Back pain | | 4 | Dizziness | | 5 | Headache | | 6 | Fatigue | | 7 | Muscle weakness or pain | | 8 | Nasal congestion | | 9 | Depression | | 10 | Skin rash | | 11 | Gastrointestinal upset (nausea, vomiting, diarrhea) | | 12 | Increased liver enzymes (rare) |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to dutasteride or any of its components | | 2 | Pregnancy and women of childbearing potential (as mentioned above) | | 3 | History of severe liver disease or liver failure | | 4 | Severe renal dysfunction (kidney problems). Always consult your healthcare provider if you have renal impairment |
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| interactions | CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase dutasteride levels. CYP3A4 inducers (e.g., rifampin) may decrease dutasteride levels. Co-administration with other drugs that affect hepatic metabolism should be carefully considered. |
| warnings and precautions | | 1 | Regular monitoring of prostate-specific antigen (PSA) levels is important. | | 2 | Patients with a history of cardiac issues, heart problems, or severe coronary artery disease should consult a cardiologist before starting the treatment | | 3 | Regular blood tests may be necessary to monitor liver function | | 4 | Avoid crushing or chewing the tablets as this can alter absorption. | | 5 | Serious allergic reactions (anaphylaxis) are rare but can occur. Seek immediate medical attention if you experience such a reaction. | | 6 | This medication should only be used as prescribed by a qualified healthcare professional. |
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| additional informations | Dutasteride is a potent 5α-reductase inhibitor, which reduces the conversion of testosterone to dihydrotestosterone (DHT). This leads to a reduction in prostate size and can improve urinary symptoms associated with BPH. |
| patient details | |
