| name | Tadalafil |
| classification | Phosphodiesterase-5 (PDE5) inhibitor |
| pharmacokinetics | | absorption | Tadalafil is well absorbed after oral administration. Peak plasma concentrations are typically reached within 2-3 hours, but can vary among individuals. Food does not significantly affect the absorption. | | distribution | Tadalafil is distributed throughout the body, including the vascular tissues. Binding to plasma proteins is moderate (approximately 96%). | | metabolism | Tadalafil is primarily metabolized in the liver by CYP3A4. This is a major factor influencing its clearance rate. | | excretion | The major route of excretion is through the urine (both unchanged drug and metabolites). Excretion is somewhat prolonged, with a half-life of approximately 17.5 hours. |
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| suggested dosage | | general | The recommended starting dose for tadalafil in the treatment of erectile dysfunction (ED) is 10 mg taken approximately 30 minutes prior to sexual activity. Dose adjustments can be made by the physician based on individual response and tolerability. A maximum dose of 20 mg once a day is typically prescribed. | | specific to patient | Given the patient's age (25) and weight (70 kg), a standard starting dose of 10 mg taken approximately 30 minutes before sexual activity is appropriate. The physician should closely monitor the patient's response and adjust dosage as needed. |
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| indications | Tadalafil is primarily indicated for the treatment of erectile dysfunction (ED) in adult males. |
| safety in pregnancy | Tadalafil is not indicated for use in pregnant women. It should not be used during pregnancy unless the potential benefits outweigh the potential risks. |
| safety in breastfeeding | Tadalafil is not recommended for use in breastfeeding women. Consult with a healthcare professional if use is necessary. |
| side effects | | 1 | Headache | | 2 | Back pain | | 3 | Muscle aches | | 4 | Nasal congestion | | 5 | Dyspepsia | | 6 | Visual disturbances (e.g., blurred vision, changes in color vision) | | 7 | Flushing | | 8 | Dizziness | | 9 | Hypotension | | 10 | Priapism (a persistent and painful erection) - rare but serious |
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| alternatives | |
| contraindications | | 1 | Patients with known hypersensitivity to tadalafil or any of its components | | 2 | Patients with certain cardiovascular conditions (e.g., unstable angina, recent myocardial infarction, or severe hypotension) | | 3 | Patients taking nitrates or nitric oxide donors (e.g., nitroglycerin). This combination can result in a dangerous drop in blood pressure. This is a CRITICAL CONTRAINDICATION. | | 4 | Patients with known retinal or macular diseases |
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| interactions | | 1 | Simultaneous use of tadalafil with nitrates or nitric oxide donors is contraindicated. | | 2 | Tadalafil may interact with certain medications affecting liver function or CYP3A4 enzymes, potentially affecting its metabolism. | | 3 | Consult with a physician regarding the use of tadalafil with other medications |
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| warnings and precautions | | 1 | Patients should be advised about the potential for adverse events including hypotension and priapism. | | 2 | Close monitoring is required for patients with pre-existing cardiovascular conditions or a history of prolonged erection. | | 3 | Patients with a history of retinitis pigmentosa or other retinal diseases should discuss the use of tadalafil with their physician. | | 4 | Patients with known significant liver or kidney disease should discuss the appropriateness of using tadalafil with their physician. Dosage adjustments may be necessary. |
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| additional informations | Tadalafil is often used as a once-daily medication for the treatment of ED. It is important to follow the prescribed dosage and to discuss any concerns or questions with your physician. |
