| name | Avanafil (Stendra) |
| classification | Phosphodiesterase-5 (PDE5) inhibitor |
| pharmacokinetics | | absorption | Rapid absorption, with peak plasma concentrations typically occurring within 30-120 minutes after oral administration. Food can delay absorption slightly. | | distribution | Distributed throughout the body, with some accumulation in the testes and prostate. Protein binding is moderate. | | metabolism | Primarily metabolized by the liver, primarily via the CYP3A4 pathway. Patients with significant hepatic impairment may require dosage adjustments. | | excretion | Elimination primarily through the kidneys, with a small portion excreted in the feces. Renal impairment may affect clearance and require dosage adjustment. |
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| suggested dosage | | initial | 100 mg, taken approximately 15-60 minutes before sexual activity. The maximum recommended dose is 200 mg once daily and should not be taken more than once in 24 hours. | | note | Individual dosage may need adjustment based on response and tolerability. Consult a healthcare professional for personalized recommendations. |
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| indications | Treatment of erectile dysfunction (ED) in adult males. |
| safety in pregnancy | Not indicated for use in pregnant women and should not be taken during pregnancy. Avanafil is not known to have a direct impact on the fetus, but as with any medication, consult with a healthcare professional before taking during pregnancy. |
| safety in breastfeeding | Not recommended for use in breastfeeding mothers due to lack of data on potential effects on breastfed infants. Consult with a healthcare professional before taking. |
| side effects | | 1 | Headache | | 2 | Facial flushing | | 3 | Nasal congestion | | 4 | Dyspepsia (indigestion) | | 5 | Back pain | | 6 | Muscle pain | | 7 | Visual disturbances (e.g., blurred vision) | | 8 | Hypotension (low blood pressure) | | 9 | Dizziness | | 10 | Myalgia (muscle aches) | | 11 | Rhinitis | | 12 | Pruritus (itching) | | 13 | Rash | | 14 | Rarely, significant, persistent vision changes or loss. |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to avanafil or any of its components | | 2 | Concurrent use of nitrates or nitric oxide donors (e.g., amyl nitrate, isosorbide dinitrate, nitroglycerin), as this combination can result in severe hypotension. | | 3 | Severe cardiovascular disease or conditions such as unstable angina or recent myocardial infarction. | | 4 | Significant liver or kidney dysfunction. | | 5 | Uncontrolled hypertension or hypotension | | 6 | Recent stroke or transient ischemic attack | | 7 | Patients with a known anatomical defect that limits blood supply to the penis (e.g., Peyronie's disease). |
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| interactions | | 1 | Nitrates (used to treat chest pain): Severe hypotension (low blood pressure) can occur. | | 2 | Alpha-blockers (used to treat high blood pressure or prostate conditions): Additive hypotensive effects are possible. This often requires close monitoring by a healthcare professional. | | 3 | Other medications metabolized by CYP3A4: Possible interactions should be discussed with a healthcare professional. |
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| warnings and precautions | | 1 | Patients with pre-existing cardiovascular conditions should be monitored closely during therapy. | | 2 | Patients with retinitis pigmentosa or other retinal diseases should use avanafil with caution. | | 3 | Avoid excessive alcohol consumption during avanafil treatment. | | 4 | Inform your healthcare professional about all medications you are taking. |
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| additional information | This information is for educational purposes only and does not constitute medical advice. Always consult with a healthcare professional before starting any new medication, especially if you have underlying health conditions or are taking other medications. This information is specific to avanafil and does not constitute a comprehensive guide to erectile dysfunction treatment. |
| patient profile | |
