| name | Tretinoin Topical |
| classification | Retinoid, Topical |
| pharmacokinetics | Tretinoin is readily absorbed into the skin. The exact mechanisms of action are still being researched but involve multiple cellular processes and interactions. It is metabolized in the liver and excreted via the kidneys and bile. Topical formulations have a relatively short duration of action. |
| suggested dosage | | male 25 70kg | Initial application: 0.025% cream or gel once daily at bedtime. If tolerated, gradually increase frequency to twice daily. May be used daily for acne or other dermatological conditions. Consult a dermatologist for precise dosage and duration of therapy. | | important note | Dosage should be individualized based on patient response and skin tolerance. Do not increase the strength or frequency of application without consulting a healthcare professional. |
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| indications | | 1 | Acne vulgaris | | 2 | Actinic keratosis | | 3 | Photoaging | | 4 | Some types of psoriasis | | 5 | Hyperpigmentation (some cases) | | 6 | Age spots/sun spots | | 7 | Comedones (blackheads/whiteheads) |
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| safety in pregnancy | Not recommended during pregnancy. Potential fetal harm is a concern. Consult a physician. |
| safety in breastfeeding | Use is not recommended during breastfeeding due to potential absorption into breast milk and theoretical risks to the infant. Consult a physician. |
| side effects | | 1 | Skin irritation (erythema, dryness, peeling, burning, or stinging) | | 2 | Increased photosensitivity (more susceptible to sunburn) | | 3 | Local skin reactions | | 4 | Temporary skin inflammation or rash | | 5 | Transient perioral dermatitis (irritation around the mouth) |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to tretinoin or other retinoids | | 2 | Severe skin conditions or active skin infections | | 3 | Severe sunburns or skin rashes |
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| interactions | | 1 | Certain topical medications (e.g., antibiotics, corticosteroids) | | 2 | Certain oral medications (check with a pharmacist) | | 3 | Increased risk of sunburns and phototoxic effects with concomitant use of photoactive drugs and/or UV exposure | | 4 | Increased risk of skin irritation with concomitant use of other irritating topical agents. |
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| warnings and precautions | | 1 | Start with low concentrations and gradually increase frequency as needed | | 2 | Apply the medication at night and avoid sun exposure during the day | | 3 | Patients should use sunscreen with an SPF of at least 30 every time they go outside | | 4 | Discontinue use if severe irritation or other adverse effects occur | | 5 | Patients with a history of rosacea or other skin conditions should use caution | | 6 | Patients should inform their physician or dermatologist of any other medications they are taking, including over-the-counter drugs and supplements. |
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| additional informations | | 1 | Tretinoin can initially worsen acne or other skin conditions before improvement | | 2 | Skin irritation usually improves with continued use | | 3 | Consistent use is essential for optimal results | | 4 | Follow your physician or dermatologist's instructions carefully. | | 5 | Consult with a physician or dermatologist before use if you have any concerns regarding your health. |
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