| name | Poly-L-lactic Acid (PLLA) Fillers |
| classification | Aesthetic / Cosmetic Injectable Filler |
| pharmacokinetics | PLLA is a biocompatible polymer that gradually degrades within the body over a period of months to years. It is not absorbed but rather resorbed as a result of the body's natural degradation processes. The specific pharmacokinetics can vary depending on the specific formulation, injection technique, and individual patient response. |
| suggested dosage | Dosage is determined by the treating physician based on the specific area to be treated, the desired aesthetic outcome, and the patient's individual anatomy. It is not possible to provide a general dosage without a clinical assessment. The amount of filler is typically measured in milliliters or units. |
| indications | Used to improve the appearance of wrinkles, folds, and depressions in the skin, particularly in the face, hands, and neck. It can also be used to add volume to specific areas. The specific indications vary greatly based on the areas being treated. |
| safety in pregnancy | Limited data available. Generally, PLLA fillers are not recommended for use during pregnancy due to lack of conclusive studies. Potential risks to the developing fetus cannot be ruled out. It is essential to discuss pregnancy plans with the physician before considering treatment. |
| safety in breastfeeding | Limited data available. Generally, PLLA fillers are not recommended for use during breastfeeding due to lack of conclusive studies regarding their potential impact on the infant. It is important to discuss breastfeeding plans with the physician before considering treatment. |
| side effects | | 1 | Swelling (edema) | | 2 | Bruising (hematoma) | | 3 | Pain | | 4 | Redness | | 5 | Tenderness at the injection site | | 6 | Infection (rare) | | 7 | Allergic reaction (rare) | | 8 | Asymmetry of treated area | | 9 | Migratory nodules | | 10 | Granuloma formation (rare) | | 11 | Skin discoloration |
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| contraindications | | 1 | Known allergy to PLLA or any of its components | | 2 | Uncontrolled infections or inflammatory conditions | | 3 | Bleeding disorders | | 4 | Pregnant or breastfeeding | | 5 | Active skin conditions at the injection site | | 6 | A history of keloid or hypertrophic scarring at the planned injection site | | 7 | Certain medical conditions where the risk of complications might be increased |
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| interactions | Limited interaction information available. No known significant drug interactions. Patient's current medications and medical conditions should be disclosed to the physician prior to treatment. |
| warnings and precautions | | 1 | Consult a qualified physician experienced in aesthetic procedures. | | 2 | Detailed patient history and medical examination are crucial before treatment. | | 3 | All potential risks, benefits, and alternatives should be fully discussed with the physician. | | 4 | Close monitoring of the treated areas is recommended. | | 5 | Follow all post-treatment instructions meticulously. |
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| additional information | PLLA is a gradual filler, meaning results may take several months or years to fully develop. The effects are also affected by the patient's metabolism and the injection technique. It is important to carefully select qualified medical professionals. |
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