| name | Piperacillin-Tazobactam |
| classification | Penicillins, carbapenems (combination) |
| pharmacokinetics | | absorption | Well absorbed after intravenous or intramuscular administration. Oral bioavailability is limited. | | distribution | Distributed widely throughout the body, including the lungs, kidneys, and bones. Penetration into cerebrospinal fluid is variable. | | metabolism | Primarily excreted unchanged in the urine. Tazobactam, the beta-lactamase inhibitor, is also excreted renally. | | elimination | Elimination is primarily renal. Dosage adjustments may be necessary in patients with renal impairment. |
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| suggested dosage | | adult 70kg | | intravenous infusion | | 1 | | route | intravenous infusion | | dosage | 3.375 g every 6 hours or 4.5 g every 8 hours |
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| | intravenous bolus | | 1 | | route | intravenous bolus | | dosage | Not recommended for bolus administration |
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| | other | | 1 | | route | alternative routes or dosages | | note | Consult a healthcare professional for the appropriate dosage in this case. |
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| indications | Broad-spectrum antibiotic used to treat bacterial infections including pneumonia, skin infections, urinary tract infections, intra-abdominal infections, and more. Effectiveness and dosage depends on severity and location of infection. |
| safety in pregnancy | Use during pregnancy only if the potential benefit outweighs the potential risk. Limited data in some cases. Consult with a physician. |
| safety in breastfeeding | Potential for excretion into breast milk. Monitor infant for adverse effects and weigh benefit vs. risk. |
| side effects | | 1 | Nausea, vomiting, diarrhea, abdominal pain, headache, rash, itching, fever | | 2 | Hypersensitivity reactions (e.g., anaphylaxis, Stevens-Johnson syndrome) | | 3 | Superinfection (e.g., yeast infections) | | 4 | Elevated liver enzymes | | 5 | Nephrotoxicity (kidney damage) |
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| contraindications | | 1 | Hypersensitivity to penicillins, cephalosporins, or other beta-lactam antibiotics | | 2 | Previous severe allergic reaction to Piperacillin-tazobactam |
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| interactions | | 1 | Aminoglycosides (potentiate nephrotoxicity) | | 2 | Probenecid (decreases renal excretion, increasing levels of piperacillin) | | 3 | Certain other medications (check drug interaction database) | | 4 | Alcohol may potentiate nausea and vomiting |
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| warnings and precautions | | 1 | Monitor renal function, especially in patients with pre-existing kidney disease. | | 2 | Monitor for signs of hypersensitivity (anaphylaxis, rash). | | 3 | Observe for signs of superinfections. | | 4 | Dosage adjustments may be needed in patients with impaired renal function. | | 5 | Use cautiously in patients with a history of gastrointestinal problems. |
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| additional informations | | 1 | Administer intravenously or intramuscularly. Dosage adjustments needed for specific infections | | 2 | Monitor blood cultures to assess treatment efficacy and response | | 3 | Patient age and kidney function play a role in dosing and monitoring | | 4 | This information is for educational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional for personalized treatment recommendations. |
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