| name | Meropenem |
| Classification | Carbapenem antibiotic |
| Pharmacokinetics | Meropenem is a broad-spectrum antibiotic that is well absorbed after intravenous administration. Its half-life is relatively short, requiring frequent dosing. The drug is distributed throughout the body and is eliminated primarily through the kidneys as active metabolite. Renal function plays a crucial role in its clearance. Adjustments to dosing are necessary for patients with impaired renal function. |
| suggested dosage | | description | Dosage of meropenem depends on the severity of the infection, patient's renal function, and other factors. Consult with a physician. | | example dosage ranges | | adult | 0.5 to 2 g IV every 8 hours. |
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| indications | | 1 | Treatment of serious bacterial infections, including pneumonia, urinary tract infections, intra-abdominal infections, skin and soft tissue infections. | | 2 | Treatment of complicated infections, including infections that are resistant to other antibiotics. |
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| Safety in pregnancy | Meropenem has been used in pregnancy and is considered generally safe. However, there is a lack of extensive studies. Use only as directed by a physician and only when potential benefits outweigh the potential risks. |
| Safety in breastfeeding | Meropenem is excreted into breast milk. The effects on the infant are not definitively known. If breastfeeding, discuss with the physician if benefits outweigh the risk. |
| side effects | | 1 | Nausea, vomiting, diarrhea | | 2 | Headache, dizziness, confusion | | 3 | Skin rash, pruritus (itching) | | 4 | Transitory elevations in liver enzymes | | 5 | Hypersensitivity reactions (including anaphylaxis) | | 6 | Superinfections (caused by overgrowth of resistant bacteria) | | 7 | Seizures (especially in patients with pre-existing seizure disorders or those with impaired renal function) |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to meropenem or other carbapenems | | 2 | Use cautiously in patients with a history of seizures or other neurological disorders. |
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| interactions | | 1 | May potentiate the effect of neuromuscular blocking agents | | 2 | May interact with other medications; consult a physician about any concomitant medications. | | 3 | Monitor closely for altered renal function if administered concomitantly with nephrotoxic medications. |
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| warnings and precautions | | 1 | Monitor for signs of bleeding | | 2 | Monitor renal function regularly, especially in patients with pre-existing renal impairment | | 3 | Use cautiously in patients with a history of seizures. | | 4 | Caution is necessary in patients with severe hepatic impairment |
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| additional information | This information is for general knowledge and educational purposes only, and does not constitute medical advice. Always consult with a qualified healthcare professional for diagnosis and treatment of any medical condition or before making any decisions related to your health or treatment. |
| patient specific notes | This information is a summary of available data and should not replace a detailed discussion with your physician. Additional information regarding your particular case may be required. Ensure to inform your physician about all pre-existing conditions, including any allergies or medical history, to enable the appropriate clinical decision making. |
