| name | Phototherapy (UVB and PUVA) |
| Classification | Phototherapy, Photochemotherapy |
| Pharmacokinetics | Phototherapy works by exposing the skin to ultraviolet (UV) radiation. UVB and PUVA are different types of phototherapy. The absorption and metabolism of UV radiation in the skin is complex and depends on factors such as skin type, intensity and duration of exposure, and individual patient characteristics. Detailed pharmacokinetic data specific to phototherapy is not always available in the same way as for ingested drugs, and the effects are more linked to the dosage and duration of the exposure rather than specific absorption/elimination characteristics. |
| suggested dosage | Dosage is highly individualized and must be determined by a qualified dermatologist or physician. It depends on the specific condition being treated, the patient's skin type, and the intensity and duration of UV exposure. Factors like age, weight and prior responses will also inform the treatment plan. There is no standardized, 'one size fits all' dosage. |
| indications | Phototherapy, specifically UVB and PUVA, is indicated for various dermatological conditions, including but not limited to psoriasis, vitiligo, eczema, and other skin conditions that respond to UV light. |
| Safety in pregnancy | Phototherapy, particularly PUVA, carries potential risks during pregnancy. While the exact risks and mechanisms are not yet fully understood, avoidance of phototherapy is often suggested during pregnancy. A physician's consultation is crucial to weigh the benefits and risks in individual cases. |
| Safety in breastfeeding | Limited data is available regarding the safety of phototherapy during breastfeeding. It's crucial to consult with a healthcare professional, especially if you're breastfeeding, before undergoing phototherapy to assess potential risks to the infant. |
| side effects | Possible side effects of phototherapy, such as skin irritation, itching, redness, burning, tanning, and sometimes more serious reactions like severe sunburns are possible, depending on the treatment protocol and individual response. Skin cancer risk is also a possibility but is heavily regulated by strict treatment protocols and frequent follow-ups. |
| alternatives | |
| contraindications | Specific contraindications include significant skin disorders, active skin infections, allergies or hypersensitivities to UV radiation, conditions that make the patient overly susceptible to sunburns, and pregnancy. |
| interactions | Phototherapy may interact with certain medications, such as retinoids, certain antibiotics, and some oral medications. The effect can be altered or amplified in certain cases; patients should always disclose all medications they are taking. |
| warnings | Strict adherence to the prescribed treatment protocol is crucial to prevent adverse effects. Overexposure to UV radiation may increase the risk of skin cancer or premature skin aging. Caution is also needed to protect the eyes, using appropriate eye shields. |
| precautions | Regular follow-up with a dermatologist is essential to monitor response, manage any adverse reactions, and adjust treatment as needed. Patients should be educated on self-monitoring and reporting unusual symptoms. Patients should use appropriate sunscreens before and after phototherapy treatments to prevent sunburn. |
| additional informations | Patient age (25) and weight (70 kg) are generally not major factors directly influencing the phototherapy protocol but are considerations in the dosage and duration of treatment. Individual responses will influence the regimen. PUVA, while effective, requires special precautions and monitoring due to its potential for serious side effects. Always consult a dermatologist for personalized guidance and proper treatment. |
