| name | Pentaerythritol Tetranitrate |
| classification | Nitrate vasodilator, Antianginal |
| pharmacokinetics | | absorption | Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations typically reached within 1-2 hours. | | distribution | Widely distributed throughout the body, including the vascular system. | | metabolism | Metabolized primarily in the liver, with a short half-life (approximately 4-6 hours). | | excretion | Excreted primarily through the kidneys as metabolites. |
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| suggested dosage | | initial | Typically starts with 2.5-5 mg taken three to four times daily. | | adjustment | Dosage may need adjustment based on individual response and tolerance. A healthcare provider should monitor and adjust as needed. | | notes | Dosage should be individualized to address the patient's specific condition and needs. |
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| indications | | 1 | Prevention and treatment of angina pectoris (chest pain) | | 2 | Treatment of certain types of hypertension |
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| safety in pregnancy | | classification | Category C | | details | Limited data exists on the safety of pentaerythritol tetranitrate during pregnancy. Potential risks and benefits should be carefully weighed by the healthcare provider. It should only be used in pregnancy if the potential benefits outweigh the potential risks. |
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| safety in breastfeeding | | classification | Not established. | | details | The drug is excreted in human breast milk. The potential risk and benefits should be carefully considered by the healthcare provider and the patient before use. If pentaerythritol tetranitrate use is determined to be necessary, careful consideration of alternative treatment options that are compatible with breastfeeding should be taken into consideration. |
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| side effects | | 1 | Headache | | 2 | Dizziness | | 3 | Lightheadedness | | 4 | Orthostatic hypotension (low blood pressure upon standing) | | 5 | Flushing | | 6 | Nausea | | 7 | Vomiting | | 8 | Tachycardia (fast heart rate) | | 9 | Fatigue | | 10 | Constipation | | 11 | Abdominal pain |
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| alternatives | |
| contraindications | | 1 | Hypersensitivity to the drug or its components | | 2 | Severe hypotension (low blood pressure) | | 3 | Severe anemia | | 4 | Severe liver or kidney disease | | 5 | Closed-angle glaucoma | | 6 | Concurrent use of other medications that lower blood pressure | | 7 | Conditions requiring significant fluid volume restriction |
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| interactions | | 1 | Alcohol | | 2 | Other antihypertensives | | 3 | Phosphodiesterase type 5 inhibitors (e.g., sildenafil) | | 4 | Some medications used for erectile dysfunction (ED) |
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| warnings and precautions | | 1 | Avoid driving or operating machinery until you know how the drug affects you. | | 2 | Be careful when getting up from a lying or sitting position to prevent dizziness or lightheadedness. | | 3 | Monitor blood pressure regularly. | | 4 | Inform your doctor of all medications you are taking. | | 5 | Inform your healthcare provider about your medical history, including cardiovascular conditions. |
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| additional informations | | 1 | Dosage should be titrated slowly and carefully to minimize side effects. Consult a healthcare professional for specific dosage recommendations. | | 2 | This information is intended for educational purposes only and should not be considered medical advice. Always consult a doctor or pharmacist before taking any medication. |
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| patient specific | | age | 25 | | weight | 70 | | notes | No specific patient-related considerations are identified, however the patient's age and weight are not factors determining dosage. Consultation with a physician is necessary. |
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