| name | Finasteride (Propecia) |
| classification | 5-alpha-reductase inhibitor |
| pharmacokinetics | Finasteride is primarily metabolized by the liver. The drug is well-absorbed orally, with peak plasma concentrations typically achieved within 1-2 hours. The drug is highly bound to plasma proteins. The elimination half-life is approximately 6-8 hours, although the effects of inhibiting DHT production can last for several weeks to months after the medication is stopped. |
| suggested dosage | | male patient 25 70kg | 1 mg orally daily. This is a standard dosage for male pattern hair loss. Consult a physician for proper dosage and monitoring. | | dosage adjustments | No dosage adjustments are typically required for patients with renal impairment, but caution is advised. Adjustments may be necessary based on individual patient factors and specific medical conditions. Consult a doctor for further information. | | other dosage forms | Finasteride is available in a variety of dosage forms, including tablets and solutions. Dosage may be adjusted depending on individual needs. Consult a doctor for appropriate forms and dosage. |
|
| indications | Treatment of male pattern hair loss (androgenetic alopecia). |
| safety in pregnancy | **ABSOLUTELY CONTRAINDICATED IN PREGNANT WOMEN OR WOMEN WHO MAY BECOME PREGNANT.** Finasteride is absorbed through the placenta. Exposure to finasteride in a developing male fetus could potentially lead to abnormal development of the male reproductive tract. Women should not handle crushed or broken tablets and should take precautions to avoid accidental exposure. *This is a critical safety concern, and pregnant women or those of childbearing potential should not handle this medication under any circumstances.* |
| safety in breastfeeding | Finasteride is not known to be excreted into breast milk, therefore, it is generally considered safe in breastfeeding mothers. Consult with a healthcare provider for individual medical advice. |
| side effects | | 1 | Decreased libido | | 2 | Erectile dysfunction | | 3 | Ejaculation disorders | | 4 | Breast tenderness or enlargement | | 5 | Depression | | 6 | Headache | | 7 | Dizziness | | 8 | Muscle weakness | | 9 | Skin rash | | 10 | Gynecomastia |
|
| alternative drugs | | 1 | | drug name | Dutasteride | | class | 5-alpha-reductase inhibitor | | notes | Similar mechanism of action, used in cases of androgenetic alopecia but with additional indication for benign prostatic hyperplasia (BPH). |
| | 2 | | drug name | Minoxidil | | class | Vasodilator | | notes | Topical application; used for hair growth, alternative to finasteride for treating male pattern hair loss. |
|
|
| contraindications | | 1 | Known hypersensitivity to finasteride or any components of the formulation | | 2 | Women of childbearing potential or pregnant women (as detailed above). | | 3 | History of severe liver problems |
|
| interactions | | 1 | Possible interactions with other medications, including certain drugs affecting liver function. Consult a doctor about other medications you are taking. | | 2 | Potentially reduced effectiveness of certain medications, for example, with some HIV medication. |
|
| warnings and precautions | | 1 | Monitor for potential side effects, particularly sexual dysfunction. Regular check-ups are important. Report any concerning symptoms immediately. | | 2 | Finasteride should only be prescribed and used according to professional medical advice. | | 3 | Inform your physician of any pre-existing medical conditions or allergies. |
|
| additional information | | 1 | The effect of finasteride on hair growth typically takes several months to be noticeable. | | 2 | The drug must be continued regularly for effects to persist. | | 3 | Do not share this medication with others. It is prescribed specifically for an individual based on their specific needs. | | 4 | Results may vary from person to person. Long-term use of finasteride may increase the risk of certain side effects. Regular physician checkups are recommended to monitor any health changes. |
|
