| drug name | Desvenlafaxine |
| classification | Selective Serotonin and Norepinephrine Reuptake Inhibitor (SSNRI) |
| pharmacokinetics | Desvenlafaxine is a primarily metabolized active metabolite of venlafaxine. It is rapidly absorbed after oral administration, with peak plasma concentrations typically occurring within 4-8 hours. The drug is highly bound to plasma proteins, primarily albumin. Metabolism primarily occurs via the CYP2D6 enzyme system. Elimination half-life is approximately 11 hours. This information is general and specific pharmacokinetic parameters might vary based on individual patient factors (e.g., liver function, concomitant medications). |
| suggested dosage | The starting dosage is typically 50 mg once daily in the morning. Dosage can be titrated upwards by 50 mg increments every few days to the optimal therapeutic level. Maintenance dosages typically range from 50 mg to 100 mg once daily. *Important Note: This is a general guideline. Individual dosage and titration schedules should be determined by a healthcare professional based on patient response and tolerance. The patient's medical history and other factors must be considered.* |
| indications | Desvenlafaxine is primarily indicated for the treatment of major depressive disorder (MDD). It may also be used for the treatment of generalized anxiety disorder (GAD), and in some cases, social anxiety disorder (SAD). |
| safety in pregnancy | Desvenlafaxine use during pregnancy is associated with potential risks. There are limited long-term data, and it's essential to weigh the potential benefits against the potential risks when considering use in pregnant women. Consult with a healthcare professional for individualized guidance. Pregnant patients should also be monitored for any adverse events. |
| safety in breastfeeding | Desvenlafaxine can be excreted into breast milk. The potential effects on the nursing infant are unknown. If breastfeeding, the potential benefits of treatment must be weighed against the potential risks to the nursing infant. Consult with a healthcare professional to discuss the risks and benefits. |
| side effects | | 1 | Nausea | | 2 | Headache | | 3 | Dizziness | | 4 | Insomnia | | 5 | Sweating | | 6 | Constipation | | 7 | Dry mouth | | 8 | Sexual dysfunction (e.g., decreased libido, anorgasmia) | | 9 | Increased blood pressure and heart rate | | 10 | Weight change | | 11 | Anxiety | | 12 | Tremor | | 13 | Diarrhea | | 14 | Sleep disturbances | | 15 | Fatigue | | 16 | Vertigo | | 17 | Loss of appetite | | 18 | Epistaxis |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to desvenlafaxine or any of its components | | 2 | Severe hepatic impairment | | 3 | Concomitant use with MAO inhibitors (within 14 days of discontinuation) | | 4 | Severe uncontrolled cardiac conditions | | 5 | Co-administration of drugs that inhibit CYP2D6, including strong inhibitors |
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| interactions | Desvenlafaxine can interact with many other medications, including those affecting CYP2D6, MAOIs, anticholinergics, and other serotonergic medications. Always inform your doctor of all medications (prescription, over-the-counter, herbal supplements) you are taking. Do not start or stop any medications without consulting your doctor, and always be honest about all aspects of your health to ensure proper medical care. |
| warnings and precautions | Patients with a history of suicidal thoughts or behaviors may be at increased risk; careful monitoring is recommended. Patients with hypertension or pre-existing cardiovascular conditions should be monitored closely. Patients with a history of seizures should be cautious. Withdrawal symptoms may occur if the medication is stopped abruptly. Tapering is usually recommended. Consult your healthcare professional about any concerns. |
| additional information | This information is for educational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional for diagnosis and treatment recommendations. The information provided does not take into account the specific medical history of an individual patient; a professional consultation is critical before starting any medication. Individual response to medications may vary. It is essential that your doctor be aware of any underlying medical conditions and other medications to ensure appropriate management. |
| patient profile | |
