| name | Demineralized Bone Matrix (DBM) |
| Classification | Biologic scaffold/growth factor modulator |
| Pharmacokinetics | DBM is not absorbed systemically. Its effect is primarily local, promoting bone regeneration at the site of implantation. Detailed pharmacokinetic data specific to DBM is limited, as the focus is on its local bioactivity rather than systemic absorption. |
| suggested dosage | Dosage and administration of DBM are highly dependent on the specific clinical indication and the type of DBM product. This is best determined by the prescribing physician in consultation with the patient. |
| indications | | 1 | Treatment of bone defects (e.g., critical-sized bone defects, non-unions, periodontal defects) | | 2 | Guided bone regeneration | | 3 | Dental applications (e.g., sinus lift procedures, guided tissue regeneration) | | 4 | Orthodontic procedures | | 5 | Treatment of certain bone diseases (e.g., osteoporosis, osteogenesis imperfecta) |
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| Safety in pregnancy | Limited data available on DBM use during pregnancy. The potential risks and benefits should be carefully evaluated by the physician, considering the specific patient's needs and the severity of the condition. |
| Safety in breastfeeding | Limited data available on DBM use during breastfeeding. The potential risks and benefits should be carefully evaluated by the physician, considering the specific patient's needs and the severity of the condition. |
| side effects | | 1 | Site-specific inflammation (e.g., pain, swelling, tenderness) | | 2 | Infection risk (if not handled/implanted properly) | | 3 | Bleeding/hematoma formation | | 4 | Local reactions at the implant site | | 5 | Rare reports of allergic reactions (hypersensitivity) |
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| alternatives | |
| contraindications | | 1 | Known allergy to DBM components or related materials | | 2 | Active local infection at the planned implant site | | 3 | Uncontrolled systemic diseases potentially affecting healing |
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| interactions | Limited interaction data exists, but DBM is primarily a local biomaterial; potential interactions are not significant. |
| warnings and precautions | | 1 | Sterile technique and meticulous surgical procedures are crucial to minimize infection risk. | | 2 | Careful consideration of the patient's overall health status is essential. | | 3 | Follow-up care is important to monitor healing and address any complications. | | 4 | DBM should only be used by qualified medical professionals with experience in bone grafting procedures. | | 5 | Patient education and understanding of procedure/limitations is critical |
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| additional informations | DBM is a natural biomaterial; variations in quality and preparation can exist between manufacturers. The clinical success of DBM depends greatly on proper surgical technique, patient selection, and post-operative care. |
| patient specific details | | age | 25 years | | weight | 70 kg | | gender | male |
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