| name | Daptomycin |
| classification | Glycopeptide antibiotic |
| pharmacokinetics | Daptomycin is primarily distributed to tissues and organs with high blood flow, like the kidneys, liver, lungs, and spleen. It is not well distributed to the central nervous system. It is eliminated through the liver and kidneys and excreted in the urine and bile. The drug has a relatively short half-life, with some variability based on renal function and severity of infection. It's important to monitor kidney function closely, as impaired renal function can prolong daptomycin's elimination and potentially increase toxicity. |
| suggested dosage | | adult | Generally, the recommended dosage for adults weighing 70 kg and above is 4 mg/kg once daily intravenously. However, dosage adjustments are necessary for patients with renal impairment. | | note | Specific dosing and duration of therapy will depend on the patient's condition and severity of infection, as determined by a healthcare provider. |
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| indications | Daptomycin is primarily indicated for the treatment of skin and soft tissue infections, including diabetic foot infections, osteomyelitis, and other serious bacterial infections, especially when other antibiotics are not suitable or effective. |
| safety in pregnancy | Daptomycin use during pregnancy is not well-studied. Its potential risks are unknown and are generally considered a category C drug, meaning there is no good evidence of safety for use in pregnancy, and possible risk exists. If used in pregnancy, the possible benefit should be weighed against the potential risk to the developing fetus. Consultation with a healthcare provider is absolutely essential. |
| safety in breastfeeding | It is unknown if daptomycin is excreted in breast milk. The potential risk to the nursing infant is not well established. If used in a breastfeeding mother, it is essential to weigh the potential benefit against the risk to the infant. Consulting with a healthcare provider is highly recommended. |
| side effects | | 1 | Nausea and vomiting | | 2 | Diarrhea | | 3 | Elevated liver enzymes (transaminases) | | 4 | Myopathy (muscle pain, weakness, or damage) | | 5 | Elevated creatine kinase (CK) | | 6 | Peripheral neuropathy | | 7 | Rash | | 8 | Pruritus | | 9 | Headache | | 10 | Fatigue | | 11 | Fever | | 12 | Infusion site reactions | | 13 | Elevated bilirubin |
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| alternatives | |
| contraindications | Patients with known severe hypersensitivity to daptomycin or other glycopeptide antibiotics. |
| interactions | Daptomycin may interact with other medications that can affect the liver or kidneys. Consult with a healthcare provider about all medications, supplements, and herbal remedies being taken to avoid potential interactions. |
| warnings and precautions | | 1 | Renal impairment may require dosage adjustments. Close monitoring of renal function is essential. | | 2 | Myopathy is a significant concern. Monitor for muscle pain, weakness, and creatine kinase elevation. Discontinue therapy if myopathy is severe. | | 3 | Regular monitoring of liver function tests is recommended. | | 4 | Risk of increased adverse events with concurrent use of statins. |
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| additional informations | Daptomycin should only be prescribed and administered by healthcare professionals. Dosing and treatment duration will be tailored to the individual patient based on their specific condition. |
| patient specific details | |
