| name | Cyclobenzaprine |
| classification | Skeletal muscle relaxant |
| pharmacokinetics | Cyclobenzaprine is primarily metabolized in the liver. It has a relatively long half-life, ranging from 16 to 38 hours, which contributes to its potential for drug accumulation and side effects, particularly with chronic use. Absorption is fairly rapid, and peak plasma concentrations are typically reached within 2-4 hours. |
| suggested dosage | | male patient 25 70kg | The typical starting dose for cyclobenzaprine is 5-10 mg three times daily, taken with food. Consult a healthcare professional for the appropriate dosage based on individual patient needs, response to treatment, and potential co-morbidities. | | important note | Higher doses and prolonged durations of use should be avoided without proper medical supervision. Dosage should be adjusted carefully based on the patient's response and potential adverse events. |
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| indications | Cyclobenzaprine is primarily used to relieve muscle spasms associated with conditions like musculoskeletal injuries (e.g., sprains, strains), and other conditions where muscle spasms or pain are prominent, such as low back pain and other types of acute muscle pain. |
| safety in pregnancy | Cyclobenzaprine is classified as a pregnancy category C. There are limited data on its use during pregnancy. Use is only advised when the potential benefit outweighs the potential risk to the fetus. Careful monitoring of the mother and fetus is essential. |
| safety in breastfeeding | Cyclobenzaprine is excreted in breast milk. The potential risk to the nursing infant is not fully known. Consult a healthcare professional to discuss whether the benefits of treatment outweigh the potential risks. |
| side effects | | 1 | Drowsiness | | 2 | Dry mouth | | 3 | Constipation | | 4 | Blurred vision | | 5 | Urinary retention | | 6 | Elevated blood pressure | | 7 | Heart palpitations | | 8 | Sleep disturbances (insomnia or excessive sleepiness) | | 9 | Confusion | | 10 | Tachycardia | | 11 | Hallucinations | | 12 | Seizures |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to cyclobenzaprine or other similar drugs. | | 2 | Narrow-angle glaucoma | | 3 | Severe liver or kidney disease | | 4 | MAOI inhibitor use within the preceding two weeks (due to potential for dangerous interactions) |
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| interactions | Cyclobenzaprine may interact with various medications, including MAOIs, antidepressants, antihistamines, and others. Always inform your doctor about all medications you are taking, including over-the-counter drugs and supplements. |
| warnings and precautions | | 1 | Patients with a history of seizures or predisposition to seizures may be at increased risk. | | 2 | Avoid driving or operating machinery if drowsiness or dizziness is a side effect. | | 3 | Be cautious when combining with alcohol or other central nervous system depressants. | | 4 | Monitor for signs of elevated liver enzymes. | | 5 | Do not exceed recommended doses and duration of therapy. | | 6 | Careful monitoring of blood pressure and heart rate during treatment is essential. |
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| additional informations | Cyclobenzaprine is generally effective in relieving muscle spasms, but the relief is usually short-term. It's important to address the underlying cause of the muscle spasm along with the treatment. |
