| name | Cefazolin |
| classification | Cephalosporin antibiotic (1st generation) |
| pharmacokinetics | Cefazolin is rapidly absorbed after intramuscular or intravenous administration. Peak plasma concentrations are typically achieved within 1-2 hours. It is distributed throughout the body, including tissues and fluids. Cefazolin is primarily eliminated by the kidneys, and the elimination half-life is approximately 1-2 hours. Renal impairment can significantly prolong the half-life, necessitating dose adjustments. |
| dosage | Dosage varies depending on the indication and severity of infection. A typical starting dose for adults is 0.5-2 g every 6-8 hours, administered intravenously or intramuscularly. Consult a physician for specific dosage recommendations based on individual patient factors (e.g., renal function, age, weight). |
| indications | Cefazolin is used to treat various bacterial infections, including skin infections, bone infections, surgical site infections, and urinary tract infections (UTIs). It is particularly effective against Gram-positive organisms. |
| safety pregnancy | Generally considered safe for use during pregnancy. However, potential benefits should be weighed against possible risks. Consult a healthcare provider for personalized recommendations. |
| safety breastfeeding | Cefazolin is excreted in breast milk. While generally considered safe, monitor the infant for any adverse effects. Consult a healthcare professional for individualized guidance. |
| side effects | | 1 | Nausea | | 2 | Vomiting | | 3 | Diarrhea | | 4 | Abdominal pain | | 5 | Allergic reactions (including rash, hives, itching, anaphylaxis) | | 6 | Superinfections (e.g., vaginal candidiasis, oral thrush) | | 7 | Headache | | 8 | Fever | | 9 | Elevated liver enzymes | | 10 | Blood dyscrasias | | 11 | Pseudomembranous colitis |
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| alternative drugs | |
| contraindications | Hypersensitivity to cephalosporins or penicillins. Use with caution in patients with a history of gastrointestinal problems or renal impairment. |
| drug interactions | Concurrent use of aminoglycosides may potentiate nephrotoxicity. Some medications may influence cefazolin's metabolism or excretion. Consult with a physician about potential interactions with other medications the patient is taking. |
| warnings and precautions | | 1 | Monitor kidney function, especially in patients with pre-existing renal problems. | | 2 | Monitor for signs of allergic reactions. | | 3 | Use with caution in patients with a history of blood disorders. | | 4 | Patients with a known penicillin allergy have a higher risk of cross-reactivity with cephalosporins. |
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| additional information | Patients should inform their healthcare provider about all medications, supplements, and allergies. Complete the course of antibiotics as prescribed to prevent recurrence of infection and potential resistance. |
| disclaimer | This information is for general knowledge only and should not be considered as a substitute for professional medical advice. Always consult with a qualified healthcare provider before making any decisions about your treatment or medication. |
