| drug name | Sertraline |
| classification | SSRI |
| pharmacokinetics | Sertraline is rapidly absorbed, with peak plasma concentrations typically reached within 6-8 hours after oral administration. The drug is highly protein bound (approximately 98%). The primary elimination route is hepatic metabolism, with a half-life of approximately 26 hours. These pharmacokinetic properties influence the dosing schedule and potential for drug interactions. |
| suggested dosage | The starting dosage for sertraline in a male patient aged 25 and weighing 70 kg is generally 50 mg daily, but this is highly individualized. Your doctor will determine the appropriate dosage for you, taking into consideration the severity of your condition and potential responses. |
| indications | Treatment of depression, anxiety disorders, panic disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). |
| safety in pregnancy | Limited data exists. Consult a physician for a risk-benefit assessment during pregnancy. The drug may cross the placenta. |
| safety in breastfeeding | Sertraline can be transferred to breast milk. The decision to use the drug during breastfeeding should be made carefully in consultation with a healthcare professional. |
| side effects | Common side effects include nausea, diarrhea, insomnia, anxiety, sexual dysfunction, and headache. Less common but more serious side effects include serotonin syndrome (interaction with other medications or higher doses). |
| alternatives | |
| contraindications | Hypersensitivity to sertraline or other components of the drug. Caution is advised with pre-existing conditions and certain interactions with other medications. |
| interactions | SSRIs can interact with many medications, including MAOIs (monoamine oxidase inhibitors), triptans, and other psychotropic drugs. Consult a physician about any concomitant medications you are taking. |
| warnings and precautions | Patients with a history of suicidal ideation, or those with pre-existing liver or kidney problems, should be closely monitored. Sudden discontinuation of SSRIs may cause discontinuation syndrome. Always consult with your physician before starting or stopping any medication. |
| additional informations | SSRIs should be used with care in individuals with a history of bipolar disorder, as it could possibly trigger a manic episode. SSRIs are often part of a broader treatment plan for mental health conditions, often in conjunction with therapy and lifestyle changes. |
