| name | Polymethylmethacrylate (PMMA) Fillers |
| classification | Dermal filler |
| pharmacokinetics | PMMA fillers are inert and do not undergo significant absorption or metabolism in the body. They remain localized at the injection site. The filler's persistence depends on the type of PMMA and the placement. There is no significant systemic absorption, though some local inflammatory and immune response may occur. |
| suggested dosage | Dosage is highly variable and depends on the specific indication and the desired aesthetic outcome. The amount, technique and placement are determined by the physician during a consultation. There is no standardized dose. |
| indications | Used for soft tissue augmentation to correct facial wrinkles and folds, add volume to the face, and reshape contours. Specifically indications may include: nasolabial folds, lips, cheeks, temples, and marionette lines. It can also be used to improve the appearance of scars or depressed areas. |
| safety in pregnancy | There are no adequate studies on PMMA fillers in pregnant women. Their safety and efficacy during pregnancy and lactation are uncertain. It's not recommended. |
| safety in breastfeeding | There is no information available on the safety of PMMA fillers in breastfeeding mothers. It's not recommended. |
| side effects | | 1 | Swelling | | 2 | Bruising | | 3 | Pain | | 4 | Redness | | 5 | Infection | | 6 | Inflammation | | 7 | Granuloma formation (nodules at injection site) | | 8 | Asymmetry | | 9 | Changes in sensation (numbness or tingling) | | 10 | Allergic reactions (rare) | | 11 | Migration of filler (less common with current types) |
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| alternatives | |
| contraindications | | 1 | Active or recent infection at the injection site | | 2 | Bleeding disorders | | 3 | Uncontrolled inflammatory conditions | | 4 | Known allergy to PMMA or other components of the filler product | | 5 | History of adverse reactions to dermal fillers | | 6 | Pregnancy or breastfeeding | | 7 | Patients with uncontrolled autoimmune disease |
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| interactions | Limited drug interactions. No significant interactions with other medications have been reported. |
| warnings and precautions | | 1 | Use by qualified and experienced medical professionals who can assess individual needs and risks | | 2 | Detailed patient consultation to evaluate medical history and identify potential contraindications. | | 3 | Detailed informed consent about potential complications and risks | | 4 | Proper injection technique is crucial to avoid complications | | 5 | Follow-up appointments and ongoing monitoring are essential | | 6 | Potential for adverse reactions (some are rare). | | 7 | Long-term effects are not fully understood. |
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| additional information | | 1 | Results vary significantly from person to person | | 2 | The duration of effect can differ depending on the filler type and the body's response. | | 3 | Possible need for repeat injections or touch-ups | | 4 | Filler can migrate from injection site over time. | | 5 | Removal is possible, although the effectiveness can be variable and may require multiple procedures |
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| patient specific considerations | | age | 25 years - generally considered a healthy age range for cosmetic procedures. Evaluate patient's expectations realistically. | | weight | 70kg - not a significant factor for PMMA filler procedure. Consider body composition and fat distribution in the area to be treated. | | medical history | Thorough medical history to determine if there are contraindications. |
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