| name | Depo-Provera (Medroxyprogesterone acetate injection) |
| classification | Progestogen-only injectable contraceptive |
| pharmacokinetics | Medroxyprogesterone acetate is a synthetic progestogen administered by intramuscular injection. It is slowly released into the bloodstream, suppressing ovulation. The duration of action varies based on individual metabolism and factors including body weight and liver function. |
| suggested dosage | 150 mg intramuscular injection every 3 months. |
| indications | |
| safety in pregnancy | Not indicated for use during pregnancy. Discontinue immediately if pregnancy occurs. |
| safety in breastfeeding | May affect milk production; consult with a healthcare professional. |
| side effects | | 1 | Weight changes | | 2 | Irregular/absent periods | | 3 | Mood changes | | 4 | Headaches | | 5 | Breast tenderness | | 6 | Acne | | 7 | Nausea | | 8 | Fatigue | | 9 | Vaginal bleeding | | 10 | Pain at injection site |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to medroxyprogesterone acetate | | 2 | Unexplained vaginal bleeding history | | 3 | Significant liver disease | | 4 | Blood clots (thromboembolic disorders) | | 5 | Breast cancer |
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| interactions | | 1 | Possible interactions with certain medications (e.g., anticonvulsants, antibiotics); consult healthcare provider. | | 2 | May affect metabolism of other drugs, potentially altering their effectiveness. |
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| warnings and precautions | | 1 | Monitor for signs of blood clots (e.g., chest pain, shortness of breath, leg pain). | | 2 | Regular checkups are essential. | | 3 | Return visits for effectiveness assessment are needed. | | 4 | Body may take several months to adjust. |
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| additional information | Return of normal periods may take several months. Discuss pre-existing conditions with a healthcare professional before use. |
