| name | Meclizine |
| classification | Antihistamine, Antivertigo |
| pharmacokinetics | Meclizine is readily absorbed after oral administration. Peak plasma concentrations are typically reached within 1-4 hours. It is extensively metabolized in the liver and primarily excreted in the urine. The elimination half-life is typically around 6-8 hours, but can be prolonged in patients with hepatic impairment. Food may slightly delay absorption, but does not significantly affect the overall extent of absorption. |
| suggested dosage | The typical dosage for adults is 25mg to 50mg by mouth, two or three times daily. Adjustments may be necessary based on individual patient response and severity of symptoms. Consult a physician for specific recommendations. |
| indications | Meclizine is primarily used to treat nausea, vomiting, and vertigo associated with motion sickness, inner ear disorders, and certain medical conditions such as Meniere's disease. It may also be used to treat dizziness and/or balance problems from benign paroxysmal positional vertigo (BPPV). |
| safety in pregnancy | Limited data on the use of meclizine during pregnancy are available. Meclizine crosses the placenta. Therefore, meclizine should be used during pregnancy only if the potential benefit outweighs the potential risk. Consult with a physician. |
| safety in breastfeeding | Meclizine is excreted in breast milk. The potential risk to the infant is generally considered to be low. However, use during breastfeeding should only be considered after careful consideration by the physician and mother, weighing the potential benefits versus risks for both. |
| side effects | | 1 | Drowsiness | | 2 | Dry mouth | | 3 | Constipation | | 4 | Blurred vision | | 5 | Headache | | 6 | Fatigue | | 7 | Nervousness | | 8 | Lightheadedness | | 9 | Rash |
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| alternatives | |
| contraindications | | 1 | Known hypersensitivity to meclizine or other antihistamines | | 2 | Narrow-angle glaucoma | | 3 | Severe liver disease | | 4 | History of severe allergic reactions | | 5 | Prostatic hyperplasia |
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| interactions | | 1 | Alcohol may enhance the sedative effects of meclizine. | | 2 | Concurrent use with other medications that affect central nervous system function (CNS depressants, including opioids, benzodiazepines, and other sedative-hypnotics) may increase the risk of drowsiness or dizziness | | 3 | CYP3A4 inhibitors (e.g., ketoconazole) may increase meclizine levels, potentially increasing side effects. |
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| warnings and precautions | Patients with pre-existing conditions such as liver or kidney disease should use meclizine with caution. Monitor for signs of drowsiness and avoid driving or operating machinery if affected. If symptoms persist or worsen, or if new symptoms develop, seek medical attention. |
| additional information | Meclizine should be taken as directed. Do not exceed the recommended dosage. Store in a cool, dry place away from direct sunlight. Inform your physician about all medications you are taking before starting meclizine. |
| patient specific details | | age | 25 years | | weight | 70 kg | | specific notes | No patient specific adjustment needed for the typical dosage at 25mg-50mg by mouth, two to three times daily. However, individual response can vary; close monitoring is advised and consult with a physician for precise recommendations. |
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