| drug name | Citrulline Malate |
| classification | Nutritional supplement, nootropic agent (in some contexts) |
| pharmacokinetics | Citrulline malate is absorbed in the intestines and quickly metabolized into arginine, a precursor to nitric oxide. The bioavailability of citrulline malate is high, and it is generally well-tolerated. The exact pharmacokinetic profile, including metabolism pathways and excretion routes, is still under ongoing investigation in different populations. Limited clinical data suggest that it doesn't accumulate in tissues in high doses. |
| suggested dosage | Dosage recommendations vary. Consult with a healthcare professional for personalized recommendations, as appropriate for the patient's needs. Typically, the dosage is from 1-15 grams daily, in single or divided doses, before or during exercise. This is a broad range and optimal dosage can depend on the reason for use. |
| indications | | 1 | Potential benefits for athletes, including improved athletic performance (e.g., endurance, power output), reduced muscle soreness, and enhanced recovery. | | 2 | Potential benefits for individuals with chronic fatigue or other conditions (further studies needed). | | 3 | May help increase blood flow and reduce blood pressure in some people. | | 4 | No conclusive evidence regarding treating cardiovascular disease or other health issues, hence not indicated. |
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| safety in pregnancy | Limited data available. Consult a healthcare professional before use during pregnancy. |
| safety in breastfeeding | Limited data available. Consult a healthcare professional before use during breastfeeding. |
| side effects | | 1 | Mild gastrointestinal effects like bloating or diarrhea have been reported in some cases, particularly with higher doses. | | 2 | Other potential side effects are generally rare and mild, if any. | | 3 | More research is needed to fully understand the potential long-term effects. |
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| contraindications | | 1 | No known contraindications with normal use, but individuals with certain health conditions should consult a healthcare professional before use. | | 2 | Individuals with a history of kidney disease should consult a doctor, as supplementation can strain the kidneys. |
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| interactions | | 1 | Potential for interactions with certain medications, particularly those affecting the kidneys or blood pressure. | | 2 | Possible interaction with other supplements, especially if high doses are taken. | | 3 | Consult a doctor or pharmacist about potential interactions with existing medications. |
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| warnings and precautions | | 1 | Not intended to treat, cure, prevent or diagnose any disease. | | 2 | Use under the guidance of a healthcare professional, especially for those with pre-existing conditions or taking medications. | | 3 | May cause temporary mild digestive discomfort for some individuals, particularly at higher doses. | | 4 | Always seek medical advice before changing or adding any supplement to your daily routine. |
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| additional informations | | 1 | Citrulline malate is considered safe for healthy adults in typical dosages. | | 2 | More research is needed to confirm the effectiveness of citrulline malate for all claimed indications. | | 3 | It is crucial to consume citrulline malate as part of a balanced diet and exercise routine for optimal results, and not as a replacement. | | 4 | Consult a healthcare professional or registered dietitian before starting any new dietary regimen. |
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| patient profile | |
