| name | Avanafil |
| classification | Phosphodiesterase-5 (PDE5) inhibitor |
| pharmacokinetics | Avanafil is rapidly absorbed after oral administration. Peak plasma concentrations are typically reached within 15-30 minutes. The drug is metabolized primarily by the cytochrome P450 3A4 (CYP3A4) enzyme system. Elimination half-life is approximately 3-5 hours. Food intake may delay the onset of action by 30-60 minutes, but does not affect the extent of absorption significantly. |
| suggested dosage | | male patient 25 70kg | | initial dosage | 100mg taken as needed, 30-60 minutes before anticipated sexual activity. | | maximum daily dose | 200mg/day (2x 100mg doses) | | important notes | Dosage should be adjusted based on patient response and tolerability. Consult a healthcare professional for personalized dosage recommendations. |
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| indications | Erectile Dysfunction (ED) in adult males. |
| safety in pregnancy | Avanafil is contraindicated during pregnancy. There are no data on its use in pregnant women, and theoretical risks to the developing fetus cannot be ruled out. |
| safety in breastfeeding | Avanafil is not recommended during breastfeeding. Limited data on its excretion into breast milk is available. The potential risk to the infant is unknown. |
| side effects | | 1 | Headache | | 2 | Facial flushing | | 3 | Nasal congestion | | 4 | Back pain | | 5 | Muscle pain | | 6 | Dyspepsia | | 7 | Diarrhea | | 8 | Visual disturbances (rare): | | 9 | Hypotension (low blood pressure), rarely | | 10 | Priapism (prolonged erection, seek immediate medical attention) | | 11 | Allergic reactions (rash, hives) |
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| alternatives | |
| contraindications | | 1 | Patients with known hypersensitivity to avanafil or any of its ingredients | | 2 | Patients taking nitrates (nitroglycerin, isosorbide dinitrate, isosorbide mononitrate) or other medications that interact with these. | | 3 | Patients with cardiovascular conditions (e.g. severe heart disease, recent stroke, or myocardial infarction) that could be worsened by vasodilators |
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| interactions | | 1 | Concurrent use with nitrates can result in a potentially dangerous drop in blood pressure. This is a serious interaction and should be avoided. | | 2 | Certain medications that inhibit the CYP3A4 enzyme can potentially increase the blood level of avanafil, increasing the risk of side effects. | | 3 | Consult a healthcare professional about any other medications you are taking. |
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| warnings and precautions | | 1 | Patients with pre-existing cardiovascular conditions (e.g., heart failure, high blood pressure), or those with any other serious medical condition should consult their doctor before using the drug. | | 2 | Avoid alcohol consumption during treatment with avanafil as it can increase the risk of certain side effects. | | 3 | Patients with retinal or other eye problems should consult their doctor before use. | | 4 | Do not take more than the recommended dose, as this can increase the risk of side effects. |
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| additional informations | This information is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare professional before taking any medication. |
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