| drug name | Autologous Chondrocyte Implantation (ACI) |
| classification | Surgical procedure |
| pharmacokinetics | Not applicable. ACI is a surgical procedure involving harvesting, culturing, and re-implanting cartilage cells. No systemic absorption or elimination in the traditional drug sense. |
| suggested dosage | Not applicable. Highly individualized based on specific site and extent of cartilage damage, determined during pre-operative planning and the surgical procedure. |
| indications | Treatment of symptomatic cartilage defects in weight-bearing joints (e.g., knee, hip, ankle) that do not respond to other therapies. |
| safety in pregnancy | Limited data. ACI should be considered after careful evaluation of patient's unique circumstances. Potential risks and benefits should be discussed with an orthopedic specialist. |
| safety in breastfeeding | Limited data. ACI should be discussed with an orthopedic specialist after careful evaluation of potential risks and benefits. |
| side effects | | 1 | Infection | | 2 | Hematoma | | 3 | Pain/swelling | | 4 | Numbness/tingling | | 5 | Delayed healing | | 6 | Rejection/poor take of implanted cells | | 7 | Incomplete repair | | 8 | Adverse reaction to anesthesia | | 9 | Stiffness/limited range of motion |
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| alternatives | |
| contraindications | | 1 | Uncontrolled infection | | 2 | Bleeding disorders | | 3 | Active inflammatory arthritis in the target joint | | 4 | Inability to tolerate anesthesia | | 5 | Unrealistic expectations | | 6 | Inability to adhere to post-operative rehabilitation |
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| interactions | No direct drug interactions. Interactions may exist with other medical conditions or therapies (e.g., anticoagulants). |
| warnings and precautions | | 1 | ACI is a complex surgical procedure with inherent risks. | | 2 | Complete evaluation and discussion with an orthopedic specialist are crucial. | | 3 | Realistic expectations are vital. | | 4 | Post-operative rehabilitation is critical for success. | | 5 | Potential for incomplete or inadequate results. | | 6 | Individual response varies. |
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| additional informations | | 1 | Patient age and weight are factors in suitability and risk/benefit assessment. A personalized treatment plan is essential. Not a first-line treatment. | | 2 | Recovery time varies. | | 3 | Long-term complications not fully understood. |
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| patient details | |
